Results 221 to 230 of about 166,829 (294)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Rare skin disease helps uncover mechanisms of acyl ceramide biosynthesis. [PDF]

J Lipid Res
Tollinger S, Ortner D, Trafoier T, Moosbrugger-Martinz V, Gruber R, Schmuth M.   +5 more
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Exploring the Venom Diversity of Australian Taipans: Comparative Characterization of <i>Oxyuranus microlepidotus</i> and <i>Oxyuranus scutellatus</i>. [PDF]

Toxins (Basel)
Paz GG, Spencer PJ, Pimenta DC, Beraldo-Neto E.   +3 more
europepmc   +1 more source

Relation entre l’annexine A6 et la phospholipase D1 pendant le processus d’exocytose dans les cellules PC12

, 2014
Le Duy Do
openalex   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Intracellular calcium release activates carotid body afferents by fentanyl. [PDF]

Function (Oxf)
Peng YJ, Kabil O, Wang N, Xie Z, Fox AP, Prabhakar NR.   +5 more
europepmc   +1 more source

Structural Basis of the Phospholipase C Activity in Neutral Sphingomyelinase from Bacillus cereus.

, 2007
Hideo Ago, Masashi Miyano
openalex   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Updated safety evaluation of the food enzyme phospholipase A₂ from the genetically modified <i>Trichoderma reesei</i> strain RF8793. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano M, Van Loveren H, Vernis L, Criado A, Liu Y.   +14 more
europepmc   +1 more source