Results 61 to 70 of about 298,796 (340)

Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]

, 1994
. Lipoprotein lipase (LPL) and glycolipidanchored cAMP-binding ectoprotein (Gcel) are modified by glycosyl-phosphatidylinositol (GPI) in rat adipocytes, however, the linkage is potentially unstable. Incubation of the cells with either insulin (0.1-30 nM)
Bandlow, Wolfhard, Dearey, Elisabeth Ann, Korndörfer, Andrea, Müller, Günter   +3 more
core   +3 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J., Gay, Claudia Carolina, Pla, Davinia, Sanz, Libia   +3 more
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Synthesis of Lysophospholipids

Molecules, 2010
New synthetic methods for the preparation of biologically active phospholipids and lysophospholipids (LPLs) are very important in solving problems of membrane–chemistry and biochemistry.
Paola D’Arrigo, Stefano Servi
doaj   +1 more source

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial [PDF]

, 2014
IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes ...
Abraham, J, Abramson, B, Acheatel, R, Ahmed, M, Akhunova, S, Alegret, JM, Alonso-Pulpón, L, Amerena, J, Amkieh, A, Amlani, M, Anand, D, Anderson, J, Antolin, JM, Areses, EL, Arkhipov, M, Aroney, C, Arstall, M, Asfour, A, Ashchi, M, Auguadro, C, Azar, R, Balog, C, Banker, D, Barbarash, O, Barbarich, V, Bash, Dianna, Battaglia, J, Belenky, D, Benczur, B, BERNI, Andrea, Berti, S, Bertolet, B, Biasucci, LM, Black, R, Blanchard, A, Blonder, R, Bokern, MJ, Bosschaert, M, Braun-Dullaeus, R, Breedveld, RW, Brennan, Danielle M., Brilakis, E, Broadwater, S, Bronisz, M, Bronzwaer, PN, Brown, A, Brown, WV, Browne, K, Burtt, D, Camp, A, Cannon, K, Cavender, JB, Cavender, Matthew A., Cendon, AA, Cervinka, P, Chandna, H, Chandra, S, Chandrashekhar, Y, Chapidze, G, Chawla, K, Chernick, R, Chronos, N, Chumburidze, V, Collins, N, Constance, C, Corrada, E, Cortés, JM, Crowley, S, Csapo, K, Cuccia, C, Dabrowski, M, Dani, S, Dart, A, Davies, C, Delafontaine, P, Della-Siega, A, DeMets, D, Den Hartog, F, den Hartoog, M, Dengler, T, Denning, S, Derlaga, B, Devlin, G, Dezsi, C, Dinnyes, J, Dobrzycki, S, Doevendans, P, Dorsel, T, Dovgalevskiy, Y, Downes, T, Drenning, D, Drozdz, J, Drzewiecki, A, East, C, Eaton, G, Edes, I, Eich, D, Elliott, J, Ermoshkina, L, Esquivias, GB, Farshid, A, Faynyk, A, Fedele, F, Fernández, JD, Ferrier, L, Feskov, O, Fineschi, M, Franco, SN, French, W, Frey, N, Fulwani, M, Gebel, J, Genth-Zotz, S, Genís, AB, Gessek, J, Gielen, S, Gillespie, E, Gniot, J, Go, B, Goloborodko, B, Goloshchekin, B, González, MJ, Gordeev, I, Gormaz, CL, Gosselin, G, Goswami, R, Goya, IL, Gunalingam, B, Gupta, S, Guseva, G, Haldis, T, Haltern, G, Harding, S, Hart, H, Heckman, MJ, Hengstenberg, C, Henry, P, Hermans, W, Herrman, J, Heuer, H, Horak, D, Horowitz, J, Hubacek, J, Huff, C, Hulinsky, V, Hutyra, M, Huynh, T, Ilmer, B, Ingelmo, JM, Janik, M, Jarne, EF, Jay, D, Jukema, J. Wouter, Kahali, D, Kancz, S, Karpenko, O, Karpenko, Y, Kashou, H, Kastelein, John J. P., Katerenchuk, O, Katzan, I, Kedhi, E, Keijzers, M, Khaisheva, L, Khintibidze, I, Kie, SH, Kiss, R, Kleiman, N, Klein, G, Klimovic, T, Klimsa, Z, Kmetzo, J, Kobulia, B, Kochmanski, M, Koenig, W, Koenig, Wolfgang, Kokis, A, Kopytsya, M, Korban, E, Kornacewicz-Jach, Z, Kostenko, V, Kovacs, Z, Koval, O, Kozhukhov, S, Kozlowski, A, Kraiz, I, Kreuzer, J, Kukuy, E, Kuznetsov, V, Lago, VN, Lai, C, Lamas, G, Lambert, C, Lapp, H, Lauer, M, Lavi, S, Leithäuser, B, Lenderink, T, Leschke, M, Libis, R, Lieberman, S, Liem, A, Lincoff, A. Michael, Linev, K, Lioy, E, Lochridge, S, Lok, D, Loussararian, A, Lu, D, Lupkovics, G, MacDonald, L, Madej, A, Magagnini, E, Mahar, L, Maly, M, Mamatsashvili, M, Mann, J, Marenzi, G, Markov, V, Marso, S, Martin Mde, M, Martin, IH, Martin, L, Mayer, O, McCullum, K, Megreladze, I, Mennuni, M, Menon, Venu, Merenda, R, Merkely, B, Miekus, P, Mikhin, V, Minisi, A, Miranda, JM, Monhart, Z, Monraats, P, Montero, JS, Moretti, L, Motovska, Z, Movahed, M, Mudra, H, Mukherjee, A, Muller, G, Musial, W, Möllmann, H, Nagy, A, Nambi, Vijay, Nava, JS, Navarro, MJ, Nicholls, Stephen J., Nierop, P, Nissen,, Nogai, K, Oei, F, Ortiz, AI, Ovcharenko, E, Paradis, JM, Parikh, K, Parker, J, Peñaranda, AS, Pfeffer, M, Piscione, F, Pleva, L, Pluta, W, Polasek, P, Polgar, P, Polk, D, Pollock, S, Ponikowski, P, Prasad, C, Prati, F, Premchand, R, Prokhorov, O, Psuja, P, Pudil, R, Pérez, MB, Rajput, R, Ramaswamy, G, Rassi, A, Reichert, P, Rekosz, J, Rezkalla, S, Richardson, J, Rivera, E, Robertson, R, Rodes-Cabau, J, Roleau, J, Romero, AJ, Romo, AI, Ronaszeki, A, Ronner, E, Rosenberg, M, Rosenson, Robert S., Rotterova, H, Rubio, AM, Ruda, M, Rudenko, L, Runquist, L, Rynkiewicz, A, Sangiorgi, G, Sanmartín, M, Sanz, M, Sanz, RR, Saucedo, J, Schwartz, G, Schwartz, Gregory G., Seigel, P, Semenka, J, Senaratne, M, Sereg, M, Shaburishvili, T, Shah, A, Shalnev, V, Shishehbor, M, Shvarts, Y, Silverman, P, Simanenkov, V, Simonyi, G, Skelding, K, Soriano, FR, Speciale, G, Spinar, J, Stellbrink, C, Steven E., Hennekens C, Stillabower, M, Strain, J, Strasser, R, Sultan, P, Suriano, P, Tans, JG, Testa, R, Thadani, U, Thompson, P, Timofeev, A, Tolerico, P., Treasure, C, Trip, MD, Trivedi, S, Troquay, R, Uchino, K, Ujda, M, Urbano, RH, Vadaganelli, P, Vakaliuk, I, Valgimigli, M, van de Wetering, ML, van der Heijden, R, van Gaal, W, van Wijk, L, Veen, G, Vertes, A, Vest, A, Vijay, N, Vishnevsky, A, Voehringer, HF, Volkova, E, Wachter, R, Werner, N, White, M, Wiley, M, Wilkins, G, Williams, J, Witkowski, A, Wright, R. Scott, Wysokinski, A, Youssef, G, Zadra, R, Zateyshchikov, D, Zishiri, E, Zubiri, JJ   +369 more
core   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Multiple and Alternative Sites Make Tau Protein an Adaptable Sticky Surface for the SH3 Domain of Fyn Kinase

Angewandte Chemie, EarlyView.
An NMR‐based study, combined with computational, calorimetric and in‐cell FRET methods, sheds light on the complex recognition mechanism between the intrinsically disordered protein Tau and the SH3 domain of Fyn kinase, highlighting how the multiple binding sites present in Tau make the protein an adaptable recognition surface that can function even ...
Roberto Tira, Giulia Leo, Laura Prandini, Carlo Giorgio Barracchia, Mariapina D'Onofrio, Luca Mollica, Stefano Capaldi, Michael Assfalg, Francesca Munari   +8 more
wiley   +2 more sources