Results 51 to 60 of about 167,459 (218)

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones

, 2013
Neurodegenerative diseases are characterized by progressive degeneration of selective neurones in the nervous system, but the underlying mechanisms involved in neuroprotection and neurodegeneration remain unclear.
Elkharaz, J, Billett, E, Ugun-Klusek, Aslihan, Bedford, L, Bedford, Lynn, Mayer, R John, Lowe, James, Mayer, RJ, Elkharaz, Jamal, Billett, Ellen, Lawler, K, Lawler, Karen, Ugun-Klusek, A, Lowe, J, Constantin-Teodosiu, D, Constantin-Teodosiu, Dumitru   +15 more
core   +1 more source

Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor. [PDF]

, 1985
Manoalide, an unusual nonsteroidal sesterterpenoid recently isolated from sponge, antagonizes phorbol-induced inflammation but not that induced by arachidonic acid, suggesting that manoalide acts prior to the cyclooxygenase step in prostaglandin ...
Lombardo, D, Dennis, EA
core   +1 more source

Perioperative Intravenous Dexamethasone Improves Pain and Functional Outcomes After Arthroscopic Rotator Cuff Repair

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the effect of perioperative dexamethasone on patient‐reported pain, functional outcomes, and minimal clinically important difference (MCID) achievement following arthroscopic rotator cuff repair. Methods Patients who underwent rotator cuff repair between 2013 and 2023 were identified and divided into groups.
Trevor D. Wolterink, Germain Craddock, Joshua P. Castle, Michael A. Gaudiani, Chimdindu Obinero, Alexander S. Jurayj, Christian A. Freitag, Nathan Y. Li, Jared Mahylis, Stephanie J. Muh   +9 more
wiley   +1 more source

Genome‑wide screening and characterization of phospholipase A (PLA)‑like genes in sorghum (Sorghum bicolor L.) [PDF]

Sorghum bicolor (L.) Moench is the fifth most cultivated crop worldwide, and it is used in many ways, but it has always gained less popularity due to the yield, pest, and environmental constraints.
Reddy, A. R., Shankhapal, A., Reddy, P S, Sapara, V J, Sapara, V. J., Shankhapal, A R   +5 more
core   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories.

, 2016
Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C, Houlden, H, H. Houlden, C. E. Arber, S. Wray, Wray, S, A. Li, Li, A   +7 more
core   +1 more source

Bacterial phospholipase A: structure and function of an integral membrane phospholipase [PDF]

, 2000
Within the large family of lipolytic enzymes, phospholipases constitute a very diverse subgroup with physiological functions such as digestion and signal transduction. Most phospholipases may associate with membranes at the lipid-water interface. However,
Dijkstra, B.W., Snijder, H.J.,, Dijkstra, B.W.,, B.W Dijkstra, Snijder, H.J., H.J Snijder   +5 more
core   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Phospholipase and proteinase production by Malassezia pachydermatis isolated in dogs with and without otitis

, 2013
Background: Malassezia pachydermatis is part of the skin microbiota of dogs and cats. M. pachydermatis has been associated with external otitis and seborrhoeic dermatitis, reported more often in dogs than in cats.
Martín Espada, María Del Carmen, Carrillo Muñoz, Alfonso J., Paya Vicens, María Jesús, Ortiz Díez, Gustavo   +3 more
core   +1 more source