Results 21 to 30 of about 59,281 (286)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy

FASEB BioAdvances, Volume 4, Issue 12, Page 775-797, December 2022., 2022
Abstract During initial maternal recognition of pregnancy (MRP), the equine embryo displays a series of unique events characterized by rapid blastocyst expansion, secretion of a diverse array of molecules, and transuterine migration to interact with the uterine surface.
Alba Rudolf Vegas, Giorgia Podico, Igor F. Canisso, Heinrich Bollwein, Thomas Fröhlich, Stefan Bauersachs, Carmen Almiñana   +6 more
wiley   +1 more source

The Effects of Bee Venom on PLA2 and Calcium Concentration in Raw 264.7 Cells

Journal of Pharmacopuncture, 2003
Objectives : The purpose of this study was to investigate the effect of Bee Venom on the lipopolysaccharide, sodium nitroprusside and hydrogen peroxide induced expression phospholipase A2 and calcium concentration in RAW 264.7 cells, a murine macrophage ...
Jong-Il Yun, Hyun-Chul Jo, Sung-Yong Sim, Kee-Hyun Kim   +3 more
doaj   +1 more source

Dietary Fish Oil and Zinc Reduced Plasma Prostaglandin E2 Content by Inhibiting Phospholipase A2 Production in Broilers

The Journal of Poultry Science, 2014
Two-factor experiment was designed to examine from lipid metabolism, proinflammatory eicosanoids, and lipid peroxidation for investigating the effects of dietary oils and zinc levels of cardiovascular system of broilers.
Guanzhong Liu, Shengying An, Jianmin Yuan, Yuming Guo, Dan Liu, Hui Chen, Renlu Huang   +6 more
doaj   +1 more source

Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis [PDF]

J. Thromb. Haemost. 2009 (7), 2096-2105, 2009
To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations.
arxiv   +1 more source

Phospholipase A2 enzyme immobilization

Grasas y Aceites, 2000
A series of several supports were tested for phospholipase A2 enzyme (Lecitase 100 S- NOVO) immobilization. This system would find a number of industrial applications such as the selective hydrolysis of soybean lecithin to obtain lysophospholipids ...
B. Maroto, C. Camusso
doaj   +1 more source

Joint association of remnant cholesterol and lipoprotein-associated phospholipase A2 with composite adverse events: A 12-year follow-up study from Asymptomatic Polyvascular Abnormalities Community study. [PDF]

Diabetes Obes Metab
Abstract Aims To explore the association of remnant cholesterol (RC) and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) with composite adverse events in a large‐scale prospective study. Methods All data were collected from the Asymptomatic Polyvascular Abnormalities Community study between 2010 and 2022.
Liu Y, Zhang L, Xu Y, Zhou T, Wu W, Zhang K, Xu R, Chen W, Xu W, Zhou Y, Zheng X, Chen B.   +11 more
europepmc   +2 more sources

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Constraints on the multiplicity of the most massive stars known: R136 a1, a2, a3, and c [PDF]

A&A 679, A36 (2023), 2023
The most massive stars known to date are R 136 a1, a2, a3, and c within the central cluster R 136a of the Tarantula nebula in the Large Magellanic Cloud (LMC), with reported masses in excess of 150-200$M_\odot$. However, the mass estimation of these stars relies on the assumption that they are single. We collected three epochs of spectroscopy for R 136
arxiv   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, EarlyView., 2023
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source