Results 21 to 30 of about 321,900 (228)
Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration. [PDF]
, 2010 BACKGROUND: An early event in the neuropathology of prion and Alzheimer's diseases is the loss of synapses and a corresponding reduction in the level of synaptophysin, a pre-synaptic membrane protein essential for neurotransmission.
Bate, Clive +2 more
core +1 more source
Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs).
Roberta Tancredi Francesco dos Santos +7 more
doaj +1 more source
Biological and Pharmaceutical Bulletin, 2004 Secretory phospholipase A2 (sPLA2) is a growing family of structurally related, disulfide-rich, low molecular weight, lipolytic enzymes with a His-Asp catalytic dyad. sPLA2s are distributed in a wide variety of vertebrate and invertebrate animals, plants, bacteria, and viruses, and there are 10 catalytically active sPLA2 isozymes in mammals.
Makoto, Murakami, Ichiro, Kudo
openaire +3 more sources
Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles [PDF]
, 2016 Active neurons increase their energy supply by dilating nearby arterioles and capillaries. This neurovascular coupling underlies blood oxygen level-dependent functional imaging signals, but its mechanism is controversial.
Attwell, D +5 more
core +2 more sources
PLoS ONE, 2014 BackgroundThe aim of this study was to assess the effects of darapladib, a selective oral investigational lipoprotein-associated phospholipase A2 inhibitor, on both plasma and plaque lipoprotein-associated phospholipase A2 activity.MethodsPatients ...
Joel L Johnson +7 more
doaj +1 more source
Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk [PDF]
, 2002 Remarkably elevated levels of phospholipase A(2) (PLA(2)) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two ...
Aufenanger, Johannes +5 more
core +1 more source
The Effects of Bee Venom on PLA2 and Calcium Concentration in Raw 264.7 Cells
Journal of Pharmacopuncture, 2003 Objectives : The purpose of this study was to investigate the effect of Bee Venom on the lipopolysaccharide, sodium nitroprusside and hydrogen peroxide induced expression phospholipase A2 and calcium concentration in RAW 264.7 cells, a murine macrophage ...
Jong-Il Yun +3 more
doaj +1 more source
The Journal of Poultry Science, 2014 Two-factor experiment was designed to examine from lipid metabolism, proinflammatory eicosanoids, and lipid peroxidation for investigating the effects of dietary oils and zinc levels of cardiovascular system of broilers.
Guanzhong Liu +6 more
doaj +1 more source
Serumanti-PLA2R antibody predicted treatment outcome in idiopathic membranous nephropathy
Linchuang shenzangbing zazhi, 2021 Objective To explore the predictive value of serum phospholipase A2 receptor antibody in determining the efficacy of rituximab in the treatment of idiopathic membranous nephropathy（IMN）.Methods From August 1,2017 to May 31,2020,a total of 120 IMN ...
Zhang Xue-qin +4 more
doaj
Phospholipase A2 enzyme immobilization
Grasas y Aceites, 2000 A series of several supports were tested for phospholipase A2 enzyme (Lecitase 100 S- NOVO) immobilization. This system would find a number of industrial applications such as the selective hydrolysis of soybean lecithin to obtain lysophospholipids ...
B. Maroto, C. Camusso
doaj +1 more source