Results 221 to 230 of about 244,532 (236)
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Chemistry and Physics of Lipids, 1999
Activation of PLC-gamma isozymes in response to various agonists involves tyrosine phosphorylation of the effector enzymes. Recent evidence indicates that PLC-gamma isozymes are additionally activated by phosphatidic acid, phosphatidylinositol 3,4,5-trisphosphate and arachidonic acid in the absence of PLC-gamma tyrosine phosphorylation.
Yun Soo Bae, Sue Goo Rhee, Fujio Sekiya
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Activation of PLC-gamma isozymes in response to various agonists involves tyrosine phosphorylation of the effector enzymes. Recent evidence indicates that PLC-gamma isozymes are additionally activated by phosphatidic acid, phosphatidylinositol 3,4,5-trisphosphate and arachidonic acid in the absence of PLC-gamma tyrosine phosphorylation.
Yun Soo Bae, Sue Goo Rhee, Fujio Sekiya
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Phospholipase C- 1: A Phospholipase and Guanine Nucleotide Exchange Factor
Molecular Interventions, 2002Although phospholipase C-gamma (PLC-gamma) participates in cellular mitogenesis, evidence indicates that the catalytic activity of PLC-gamma (to hydrolyze certain phosphoinositides) is nonessential to the process. So how is it that PLC-gamma is necessary but its lipase activity is not?
Michael Moran, Zhixiang Wang
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REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D
Annual Review of Biochemistry, 1997This review focuses on two phospholipase activities involved in eukaryotic signal transduction. The action of the phosphatidylinositol-specific phospholipase C enzymes produces two well-characterized second messengers, inositol 1,4,5-trisphosphate and diacylglycerol.
H. A. Brown +2 more
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Phospholipase D in cell signalling and its relationship to phospholipase C
Life Sciences, 1991Phospholipases C and D are phosphodiesterases which act on phospholipid head groups. Although the presence of these enzymes in living organisms has long been known, it is only recently that their role in cell signal transduction has been appreciated. The new developments on phospholipases D (PLD) are especially noteworthy, since these enzymes catalyze ...
Shivendra D. Shukla, Stephen P. Halenda
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Cloning of cDNA Encoding Rat Phospholipase C-β4, a New Member of the Phospholipase C
Biochemical and Biophysical Research Communications, 1993Phospholipase C-beta 4(PLC-beta 4), a new member of phospholipase C isozyme, was purified from bovine cerebellum. The cDNA encoding rat PLC-beta 4 has been cloned from a cDNA library prepared from rat brain. The predicted open reading frame encodes a protein of 1,176 amino acids with a calculated molecular weight of 134,552.
BAHK, YY +5 more
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Phosphatidylinositol specific phospholipases C
Life Sciences, 1982The role of phosphatidylinositol-specific phospholipase C (PIase C) in a) the enigmatic phosphatidylinositol (PI) turnover and b) in our understanding of membrane enzyme-PI interactions is the subject matter of this article. PIase C is present in both procaryotes and eukaryotes.
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Phospholipases C and Phospholipases D of Mammalian Cells
1987As with Chapters 6 and 7, which covered mammalian acyl hydrolases, emphasis is on the characterization and purification of the mammalian phosphodiesterases; studies on their physiologic roles are covered in Chapter 11.
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Phospholipase C and Blood Platelets
Thrombosis and Haemostasis, 1979Anne-Brit Otnaess, Hans Prydz
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