Results 221 to 230 of about 19,781,572 (286)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Stimulation of phospholipase C-mediated hydrolysis of phosphoinositides by adenosine 5'-triphosphate via P2-purinoceptors in cultured rat aortic vascular smooth muscle cells.

, 1988
Terutaka Tsuda, Yasuhiro Kawahara, Yasuo Fukumoto, Yoshimi Takai, Hisashi Fukuzaki   +4 more
openalex   +2 more sources

Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF: not just ICSI failure. [PDF]

Asian J Androl
Che JF, Wu HX, Zeng SC, Wu YR, Dai J, Cheng DH, Gong F, Lu GX, Lin G, Dai C.   +9 more
europepmc   +1 more source

Elucidation of the zinc binding site in KCNQ channels

British Journal of Pharmacology, EarlyView.
Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and zinc binding sites within KCNQ channels are
Shuo Zhang, Xinhe Yang, Meng Yang, Yixue Cao, Sai Shi, Nikita Gamper, Haixia Gao   +6 more
wiley   +1 more source

Exploring Siglecs: Potential Modulators of Immune Cells in Food Allergy and Therapeutic Applications

Clinical &Experimental Allergy, EarlyView.
Sialic acid‐binding immunoglobulin‐type lectins (Siglecs) are inhibitory receptors present on all immune cells involved in the allergic reaction. Currently, research is mostly focussed on targeting Siglecs on mast cells to possibly treat food allergies.
J. S. H. Schaapherder, K. C. M. Verhoeckx, A. M. Ehlers, E. F. Knol, A. C. Knulst, L. A. P. M. Meulenbroek   +5 more
wiley   +1 more source

Identification of a novel homozygous missense mutation in the Phospholipase C, delta-1 gene associated with leukonychia in a Middle Eastern patient. [PDF]

JAAD Case Rep
Conway J, Henry TJ, Cohen LL, Ricardo JW, Lipner SR.   +4 more
europepmc   +1 more source

Six New Cases of 22q13.2 Gain Including TFC20: First Report of Triplication and Smallest Duplication Associated With Neurodevelopmental Delays

Clinical Genetics, EarlyView.
This study reports six new cases of 22q13.2 duplication and triplication, including the TCF20 gene, associated with neurodevelopmental disorders and various morphological and systemic abnormalities. The findings suggest a variable expressivity, but their complete penetrance remains uncertain compared to well‐established loss‐of‐function variants ...
Etienne Bizot, Dima Jouni, Caroline Rooryck, Juliet Taylor, Marine Legendre, Lorelei Charbonnier, Julia Metreau, Emmanuelle Benaloun, Audrey Pinson, Geneviève Quenum, Jérôme Bouligand, Gérard Tachdjian, Philippe Labrune, Lucie Tosca   +13 more
wiley   +1 more source

Regulating the Plasticity of Hippocampal Neurons via Electroacupuncture in Depression Model Mice

Cell Proliferation, EarlyView.
This study explores the regulation of the plasticity of hippocampal neurons via electroacupuncture in corticosterone‐induced depression model mice. Electroacupuncture at the Zusanli (ST36) acupoint alleviated depression‐like symptoms and enhanced neuronal plasticity in the hippocampal CA1 region by upregulating BDNF and CaMKIIβ, highlighting its ...
Yiyang Wang, Xinyi Du, Chenxi Duan, Miaomiao Wang, Ying Zhu, Lihua Wang, Jun Hu, Yanhong Sun   +7 more
wiley   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source