Results 41 to 50 of about 244,532 (236)

Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

Journal of Lipid Research, 2001
Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar, Stephanie Mott, Betsie Boucher, Ching Yin Lee, Michel Marcil, Jacques Genest, Jr.   +5 more
doaj  

Fungistatic effect of Gracilaria verrucosa on phospholipase enzymes and the cell surface hydrophobicity of Candida albicans

Dental Journal
Background: Candida albicans (C. albicans) was reported as a primary cause of oral candidiasis. Phospholipase enzymes and cell surface hydrophobicity (CSH) are involved in the pathogenesis of its infection. Gracilaria verrucosa (G. verrucosa) is reported
Basri A. Gani, Ridha Andayani, Fitri Yunita Batubara, Ifwandi Ifwandi, Dharli Syafriza, Muhammad Mas'ud Herlambang, Shiti Alya Fathirah, Ayudia Rifki   +7 more
doaj   +1 more source

Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)* [PDF]

, 2016
Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways.
Ashley, Jason W, Bone, Robert N, Hancock, William D, Nelson, Alexander J, Ramanadham, Sasanka, Tse, Hubert M, Turk, John, Wohltmann, Mary   +7 more
core   +2 more sources

On the interactions of lipids and proteins in the red blood cell membrane [PDF]

, 1970
The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements.
Chan, Sunney I., Glaser, Michael, Sheetz, Michael, Simpkins, Henry, Singer, S. J.   +4 more
core  

Immunization with the C-domain of α-toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens [PDF]

, 2013
© 2004 by the Infectious Diseases Society of America. All rights reserved.Clostridium perfringens gas gangrene is characterized by rapid tissue destruction, impaired host response, and, often, death. Phospholipase C (α-toxin) is the virulence factor most
Bayer, Clifford R., Bryant, Amy E., Hayes-Schroer, Susan M., Jepson, Marie, Stevens, Dennis L., Titball, Richard W.   +5 more
core   +1 more source

Recent Advances in the Cellular and Developmental Biology of Phospholipases in Plants

Frontiers in Plant Science, 2019
Phospholipases (PLs) are lipid-hydrolyzing enzymes known to have diverse signaling roles during plant abiotic and biotic stress responses. They catalyze lipid remodeling, which is required to generate rapid responses of plants to environmental cues ...
Tomáš Takáč, Dominik Novák, Jozef Šamaj   +2 more
doaj   +1 more source

Undercovering the molecular mechanisms of lipid signalling at ER-PM contact sites in tomato (Solanum lycopersicum) under abiotic stress conditions [PDF]

, 2019
Abiotic stresses cause large reductions in crop production. Therefore, is important to understand how plants respond in order to develop varieties with increased resistance.
Benítez de la Fuente, Francisco, Botella-Mesa, Miguel Angel, García-Hernández, Selene, Ruiz-López, Noemi   +3 more
core  

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Beaven, Michael A., Gilfillan, Alasdair M., Kim, Mi-Sun, Kuehn, Hye Sun, Metcalfe, Dean D., Swindle, Emily J.   +5 more
core   +1 more source

Phospholipase C isozymes as effectors of Ras superfamily GTPases

Journal of Lipid Research, 2009
The physiological effects of many extracellular stimuli are initiated through receptor-promoted activation of phospholipase C and inositol lipid signaling pathways.
T. Kendall Harden, Stephanie N. Hicks, John Sondek   +2 more
doaj  

A comparative study on production of extracellular hydrolytic enzymes of Candida species isolated from patients with surgical site infection and from healthy individuals and their co-relation with antifungal drug resistance

BMC Microbiology, 2020
Background Surgical site infection (SSI) is a crucial dilemma of surgery. Patients with SSIs not only face difficulty in treatment but also bear extra cost with high mortality rate.
Rakhshanda Erum, Farkhunda Samad, Adnan Khan, Shahana Urooj Kazmi   +3 more
doaj   +1 more source