Results 31 to 40 of about 18,826,497 (287)

Current data on the effectiveness of gliclazide and molecular mechanisms of action of the drug

Сахарный диабет, 2020
With the growing prevalence of type 2 diabetes mellitus (T2DM) the possibility of treating it with available drugs is one of the main issues. Although glycemic control and reduction of micro- and macrovascular outcomes remain important aspects of ...
Nina A. Petunina, Irina A. Kuzina, Ludmila V. Nedosugova   +2 more
doaj   +1 more source

Lipid levels in sperm, eggs, and during fertilization in Xenopus laevis

Journal of Lipid Research, 2008
Critical developmental periods, such as fertilization, involve metabolic activation, membrane fusion events such as sperm-egg or plasma membrane-cortical granule merger, and production and hydrolysis of phospholipids.
Douglas W. Petcoff, William L. Holland, Bradley J. Stith   +2 more
doaj   +1 more source

Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini

Journal of Lipid Research, 2002
Exogenous ATP stimulated phospholipase D (PLD), but not sphingomyelinase in rat submandibular gland (SMG) acini. PLD activation was dependent upon extracellular Ca2+ and did not involve intracellular Ca2+ mobilization or phosphoinositide-specific ...
Encarnación Pérez-Andrés, María Fernández-Rodriguez, Mónica González, Ana Zubiaga, Ainara Vallejo, Itxaso García, Carlos Matute, Stéphanie Pochet, Jean Paul Dehaye, Miguel Trueba, Aida Marino, Antonio Gómez-Muñoz   +11 more
doaj   +1 more source

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth [PDF]

, 2015
We gratefully acknowledge financial support from the Wellcome Trust (Grant No. WT089803MA to J.M.L.) and the School of Medicine, University of St Andrews.Neurite growth is central to the formation and differentiation of functional neurons and recently ...
Mohammed Arastoo, John M. Lucocq, Hacker, Christian, Lucocq, John Milton, Arastoo, Mohammed, Popovics, Petra, Stewart, Alan J., Christian Hacker, Alan J. Stewart, Petra Popovics   +9 more
core   +1 more source

Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach

Pathogens, 2019
In order to survive as extracellular parasites in the mammalian host environment, Trypanosoma brucei has developed efficient mechanisms of immune system evasion, which include the abundant expression of a variable surface glycoprotein (VSG) coat.
Cláudia Jassica Gonçalves Moreno, Taffarel Torres, Marcelo Sousa Silva   +2 more
doaj   +1 more source

Lipid vesicle fusion induced by phospholipase C activity in model bile.

Journal of Lipid Research, 1993
Using a system of phosphatidylcholine-cholesterol vesicles to model the vesicle phase of mammalian bile (1:1 molar ratio) we evaluated whether very small amounts of C.
TE Little, H Madani, SP Lee, EW Kaler
doaj   +1 more source

Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ladds, Graham, Aletrari, Mina-Olga, Hodgkin, Matthew N., Farquhar, Michelle J., Wright, Michelle H.   +4 more
core   +1 more source

Nuclear inositides

European Journal of Histochemistry, 2009
DAG, 1,2-diacylglycerol; EGF, epidermal growth factor; TNF, tumour necrosis factor; IGF-I, insulinlike growth factor I; Ins(n)P, inositol phosphate; Ins(n,n)P2, inositol bisphosphate; Ins(n,n,n)P3, inositol trisphosphate; MEL, murine erythroleukemia ...
C D'Santos, JH Clarke, M Roefs, JR Halstead, N Divecha   +4 more
doaj   +3 more sources

Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists. [PDF]

, 1989
The phospholipase C-catalysed breakdown of inositol-containing phospholipids is an important source of diacylglycerol in cells stimulated by several agonists.
Larrodera, Pilar, López Barahona, Mónica, Díaz Meco, María T., Barreno, P., Cornet, María E., Moscat, Jorge   +5 more
core   +1 more source