Results 11 to 20 of about 245,381 (200)

Phospholipase C [PDF]

, 2019
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times
Colin A, Bill, Charlotte M, Vines
openaire   +2 more sources

Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain

Molecules, 2022
Phospholipase is an enzyme that hydrolyzes various phospholipid substrates at specific ester bonds and plays important roles such as membrane remodeling, as digestive enzymes, and the regulation of cellular mechanism.
Yunseok Heo, Inhwan Lee, Sunjin Moon, Ji-Hye Yun, Eun Yu Kim, Sam-Yong Park, Jae-Hyun Park, Woo Taek Kim, Weontae Lee   +8 more
doaj   +1 more source

Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

Journal of Lipid Research, 2001
Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar, Stephanie Mott, Betsie Boucher, Ching Yin Lee, Michel Marcil, Jacques Genest, Jr.   +5 more
doaj   +1 more source

Phospholipase C isozymes as effectors of Ras superfamily GTPases

Journal of Lipid Research, 2009
The physiological effects of many extracellular stimuli are initiated through receptor-promoted activation of phospholipase C and inositol lipid signaling pathways.
T. Kendall Harden, Stephanie N. Hicks, John Sondek   +2 more
doaj   +1 more source

Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a [PDF]

, 2008
Stimulation of mammalian cells frequently initiates phospholipase D-catalysed hydrolysis of phosphatidylcholine in the plasma membrane to yield phosphatidic acid (PA) a novel lipid messenger.
Ahn, Avila-Flores, Brown, Cazzolli, Chen, Cross, Degterev, Du, Earnshaw, Farquhar, Fisher, Graham Ladds, Guimaraes, Hodgkin, Hui, Iwasaki-Bessho, Kasai, Kusner, Lim, Matthew N. Hodgkin, McDermott, Michelle H. Wright, Michelle J. Farquhar, Mina-olga Aletrari, Nakashima, Nozawa, Oh, O’Luanaigh, Palicz, Park, Ponting, Powner, Powner, Rozengurt, Samejima, Shi, Timmer, Wissing, Xie, Yamada, Zeniou-Meyer, Zhao, Zheng, Zhong   +43 more
core   +1 more source

Lipid levels in sperm, eggs, and during fertilization in Xenopus laevis

Journal of Lipid Research, 2008
Critical developmental periods, such as fertilization, involve metabolic activation, membrane fusion events such as sperm-egg or plasma membrane-cortical granule merger, and production and hydrolysis of phospholipids.
Douglas W. Petcoff, William L. Holland, Bradley J. Stith   +2 more
doaj   +1 more source

Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini

Journal of Lipid Research, 2002
Exogenous ATP stimulated phospholipase D (PLD), but not sphingomyelinase in rat submandibular gland (SMG) acini. PLD activation was dependent upon extracellular Ca2+ and did not involve intracellular Ca2+ mobilization or phosphoinositide-specific ...
Encarnación Pérez-Andrés, María Fernández-Rodriguez, Mónica González, Ana Zubiaga, Ainara Vallejo, Itxaso García, Carlos Matute, Stéphanie Pochet, Jean Paul Dehaye, Miguel Trueba, Aida Marino, Antonio Gómez-Muñoz   +11 more
doaj   +1 more source

Current data on the effectiveness of gliclazide and molecular mechanisms of action of the drug

Сахарный диабет, 2020
With the growing prevalence of type 2 diabetes mellitus (T2DM) the possibility of treating it with available drugs is one of the main issues. Although glycemic control and reduction of micro- and macrovascular outcomes remain important aspects of ...
Nina A. Petunina, Irina A. Kuzina, Ludmila V. Nedosugova   +2 more
doaj   +1 more source

Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk [PDF]

, 2002
Remarkably elevated levels of phospholipase A(2) (PLA(2)) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two ...
Aufenanger, Johannes, Bertsch, Thomas, Fassbender, Klaus, Quintel, Michael, Samman, Michael, Zimmer, Wilma   +5 more
core   +1 more source

Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach

Pathogens, 2019
In order to survive as extracellular parasites in the mammalian host environment, Trypanosoma brucei has developed efficient mechanisms of immune system evasion, which include the abundant expression of a variable surface glycoprotein (VSG) coat.
Cláudia Jassica Gonçalves Moreno, Taffarel Torres, Marcelo Sousa Silva   +2 more
doaj   +1 more source