Results 171 to 180 of about 200,907 (241)

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease. [PDF]

PLoS Genet, 2021
Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS.   +12 more
europepmc   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye, Claire Pearson, Tibyan Babiker, Emilio Agostinelli, Rumaitha Al‐Hosni, Paolo Tammaro   +5 more
wiley   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source

Opioid receptors in cardiovascular function

British Journal of Pharmacology, EarlyView.
Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari, Kesha K. Dalal, Narendra Kondapalli, Sailaja Paruchuri, Charles K. Thodeti   +4 more
wiley   +1 more source

EZR-PLC and RhoGTPases interactions in osteosarcoma pathogenesis and metastatic process [PDF]

, 2014
LEOPIZZI, MARTINA
core   +1 more source

Toxicological Characterization and Phospholipase D Activity of the Venom of the Spider Sicarius thomisoides. [PDF]

Toxins (Basel), 2020
Arán-Sekul T, Perčić-Sarmiento I, Valencia V, Olivero N, Rojas JM, Araya JE, Taucare-Ríos A, Catalán A.   +7 more
europepmc   +1 more source

The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2. [PDF]

Exp Physiol
Thompson KJ, Watson S, Zanato C, Dall'Angelo S, De Nooij JC, Pace-Bonello B, Shenton FC, Sanger HE, Heinz BA, Broad LM, Grosjean N, McQuillian JR, Dubini M, Pyner S, Greig I, Zanda M, Bleakman D, Banks RW, Bewick GS.   +18 more
europepmc   +1 more source

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source

Regulating the Plasticity of Hippocampal Neurons via Electroacupuncture in Depression Model Mice

Cell Proliferation, EarlyView.
This study explores the regulation of the plasticity of hippocampal neurons via electroacupuncture in corticosterone‐induced depression model mice. Electroacupuncture at the Zusanli (ST36) acupoint alleviated depression‐like symptoms and enhanced neuronal plasticity in the hippocampal CA1 region by upregulating BDNF and CaMKIIβ, highlighting its ...
Yiyang Wang, Xinyi Du, Chenxi Duan, Miaomiao Wang, Ying Zhu, Lihua Wang, Jun Hu, Yanhong Sun   +7 more
wiley   +1 more source