Results 11 to 20 of about 308,555 (173)

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.

open access: yesPLoS Genetics, 2021
Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this gene confers increased risk for the development of Alzheimer's disease (AD), although the ...
Alex G Nackenoff   +12 more
doaj   +1 more source

Regulation of phospholipase D [PDF]

open access: yesFEBS Letters, 1999
Structural studies of plant and bacterial members of the phospholipase D (PLD) superfamily are providing information about the role of the conserved HKD domains in the structure of the catalytic center and the catalytic mechanism of mammalian PLD isozymes (PLD1 and PLD2).
openaire   +4 more sources

Influence of Lipid Heterogeneity and Phase Behavior on Phospholipase A2 Action at the Single Molecule Level [PDF]

open access: yesBiophys. J. 2010, 98: 1873-1882, 2009
We monitored the action of phospholipase A2 (PLA2) on L- and D-dipalmitoylphosphatidylcholine (DPPC) Langmuir monolayers by mounting a Langmuir-trough on a wide-field fluorescence microscope with single molecule sensitivity. This made it possible to directly visualize the activity and diffusion behavior of single PLA2 molecules in a heterogeneous ...
arxiv   +1 more source

Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. [PDF]

open access: yesPLoS ONE, 2010
BackgroundPhospholipase D (PLD) catalyzes conversion of phosphatidylcholine into choline and phosphatidic acid, leading to a variety of intracellular signal transduction events.
Fumio Yoshikawa   +14 more
doaj   +1 more source

Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain

open access: yesMolecules, 2022
Phospholipase is an enzyme that hydrolyzes various phospholipid substrates at specific ester bonds and plays important roles such as membrane remodeling, as digestive enzymes, and the regulation of cellular mechanism.
Yunseok Heo   +8 more
doaj   +1 more source

Detection of virulence factors and beta-lactamase encoding genes among the clinical isolates of Pseudomonas aeruginosa [PDF]

open access: yesInternational Journal of Pharmaceutical Research, 2019, 2019
Background: Pseudomonas aeruginosa has emerged as a significant opportunistic bacterial pathogen that causes nosocomial infections in healthcare settings resulting in treatment failure throughout the world. This study was carried out to compare the relatedness between virulence characteristics and \b{eta}-lactamase encoding genes producing Pseudomonas ...
arxiv   +1 more source

On the Complexity of Distance-$d$ Independent Set Reconfiguration [PDF]

open access: yesTheoretical Computer Science 1009 (2024) 114682, 2022
For a fixed positive integer $d \geq 2$, a distance-$d$ independent set (D$d$IS) of a graph is a vertex subset whose distance between any two members is at least $d$. Imagine that there is a token placed on each member of a D$d$IS. Two D$d$ISs are adjacent under Token Sliding ($\mathsf{TS}$) if one can be obtained from the other by moving a token from ...
arxiv   +1 more source

Soybean phospholipase D activity determination. A comparison of two methods

open access: yesGrasas y Aceites, 2007
Due to a discrepancy between previously published results, two methods to determine the soybean phospholipase D activity were evaluated. One method is based on the extraction of the enzyme from whole soybean flour, quantifying the enzyme activity on the ...
E. Tosi, G. Ballerini, E. Ré
doaj   +1 more source

Transphosphatidylation by Phospholipase D

open access: yesJournal of Biological Chemistry, 1967
Abstract Transphosphatidylase activity was recognized in several plant tissues as well as in extracts. It was attributed to phospholipase D. This enzyme was purified 110-fold from Savoy cabbage. The ratio of its hydrolase to its transphosphatidylase activity remained constant throughout the purification. Additional evidence supports the conclusion that
Sofia M. Freer   +2 more
openaire   +2 more sources

Phospholipase D in the Golgi apparatus [PDF]

open access: yesBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009
Phospholipase D has long been implicated in vesicle formation and vesicular transport through the secretory pathway. The Golgi apparatus has been shown to exhibit a plethora of mechanisms of vesicle formation at different stages to accommodate a wide variety of cargo.
Dennis Shields   +2 more
openaire   +3 more sources

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