Results 11 to 20 of about 122,680 (213)

Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia. [PDF]

open access: yesPLoS ONE, 2010
BackgroundPhospholipase D (PLD) catalyzes conversion of phosphatidylcholine into choline and phosphatidic acid, leading to a variety of intracellular signal transduction events.
Fumio Yoshikawa   +14 more
doaj   +1 more source

Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini

open access: yesJournal of Lipid Research, 2002
Exogenous ATP stimulated phospholipase D (PLD), but not sphingomyelinase in rat submandibular gland (SMG) acini. PLD activation was dependent upon extracellular Ca2+ and did not involve intracellular Ca2+ mobilization or phosphoinositide-specific ...
Encarnación Pérez-Andrés   +11 more
doaj   +1 more source

Soybean phospholipase D activity determination. A comparison of two methods

open access: yesGrasas y Aceites, 2007
Due to a discrepancy between previously published results, two methods to determine the soybean phospholipase D activity were evaluated. One method is based on the extraction of the enzyme from whole soybean flour, quantifying the enzyme activity on the ...
E. Tosi, G. Ballerini, E. Ré
doaj   +1 more source

Effects of Phospholipase D Inhibitors Treatment on Membrane Lipid Metabolism of Postharvest Banana Fruit in Response to Mechanical Wounding Stress

open access: yesHorticulturae, 2022
Banana fruit is a widely cultivated and economically important crop, and it is susceptible to mechanical damage. The effects of three different phospholipase D inhibitors (0.1% n-butanol, 0.05% 2-butanol, and 0.1% hexanal) on the cell membrane integrity ...
Li Li   +16 more
doaj   +1 more source

Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

open access: yesJournal of Lipid Research, 2001
Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar   +5 more
doaj   +1 more source

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.

open access: yesPLoS Genetics, 2021
Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this gene confers increased risk for the development of Alzheimer's disease (AD), although the ...
Alex G Nackenoff   +12 more
doaj   +1 more source

Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain

open access: yesMolecules, 2022
Phospholipase is an enzyme that hydrolyzes various phospholipid substrates at specific ester bonds and plays important roles such as membrane remodeling, as digestive enzymes, and the regulation of cellular mechanism.
Yunseok Heo   +8 more
doaj   +1 more source

Phosphatidic acid: a lipid regulator of the Hippo pathway

open access: yesMolecular & Cellular Oncology, 2019
The Hippo pathway, a signaling pathway highly conserved across species, plays a crucial role in organ size control and cancer suppression. Our recent study shows that phosphatidic acid can regulate the Hippo pathway through a physical lipid-protein ...
Han Han   +3 more
doaj   +1 more source

Molecular diversity of phospholipase D in angiosperms

open access: yesBMC Genomics, 2002
Background The phospholipase D (PLD) family has been identified in plants by recent molecular studies, fostered by the emerging importance of plant PLDs in stress physiology and signal transduction.
Cvrčková Fatima   +3 more
doaj   +1 more source

Nuclear inositides

open access: yesEuropean Journal of Histochemistry, 2009
DAG, 1,2-diacylglycerol; EGF, epidermal growth factor; TNF, tumour necrosis factor; IGF-I, insulinlike growth factor I; Ins(n)P, inositol phosphate; Ins(n,n)P2, inositol bisphosphate; Ins(n,n,n)P3, inositol trisphosphate; MEL, murine erythroleukemia ...
C D'Santos   +4 more
doaj   +3 more sources

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