Results 121 to 130 of about 22,290,738 (402)
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Intraspecific Variation of Centruroides Edwardsii Venom from Two Regions of Colombia
Toxins, 2014 We report the first description studies, partial characterization, and intraspecific difference of Centruroides edwardsii, Gervais 1843, venom. C. edwardsii from two Colombian regions (Antioquia and Tolima) were evaluated.
Sebastián Estrada-Gómez +3 more
doaj +1 more source
Advanced Science, EarlyView.PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li +8 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Apolipoprotein B exhibits phospholipase A1 and phospholipase A2 activities
FEBS Letters, 1993 Low density lipoproteins (LDL) as well as isolated apolipoprotein B (ApoB) have been shown to exhibit phospholipase A2 (PLA2) activity toward phospholipids containing an oxidized or short fatty acyl chain at position 2. Some of these studies employed the fluorescent analogue of phosphatidyl choline (PC), C6‐NBD‐PC, containing NBD‐caproic acid (C6‐NBD ...
Reisfeld, Nurit +3 more
openaire +2 more sources
Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]
, 2019 Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna +6 more
core +2 more sources
Advanced Science, EarlyView.The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen +7 more
wiley +1 more source
Recombinant Lipases and Phospholipases and Their Use as Biocatalysts for Industrial Applications
International Journal of Molecular Sciences, 2015 Lipases and phospholipases are interfacial enzymes that hydrolyze hydrophobic ester linkages of triacylglycerols and phospholipids, respectively. In addition to their role as esterases, these enzymes catalyze a plethora of other reactions; indeed ...
G. M. Borrelli, D. Trono
semanticscholar +1 more source
Detection of microbes in the subsurface [PDF]
The search for evidence of microbial life in the deep subsurface of Earth has implications for the Mars Rover Sampling Return Missions program. If suitably protected environments can be found on Mars then the instrumentation to detect biomarkers could be
Tunlid, Anders, White, David C.
core +1 more source
The CAMP-binding Ectoprotein from Saccharomyces cereuisiae Is Membrane-anchored by Glycosyl-Phosphatidylinositol [PDF]
, 1992 Saccharomyces cerevisiae contains an amphiphilic CAMP-binding glycoprotein at the outer face of the plasma membrane (M, = 54,000). It is converted to a hydrophilic form byt reatment withg lycosyl-phosphatidylinositol- specific phospholipases C and D ...
Bandlow, Wolfhard +3 more
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