Results 141 to 150 of about 22,290,738 (402)

A phospholipase linkAGE to SARS susceptibility [PDF]

Journal of Experimental Medicine, 2015
![Figure][1] Insight from John Schoggins During the aging process, immune functions decline, rendering the host more vulnerable to certain viruses. The mechanisms underlying this age-dependent susceptibility to infection are an active area of research.
openaire   +2 more sources

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins[S]

Journal of Lipid Research, 2010
Exosomes are bioactive vesicles released from multivesicular bodies (MVB) by intact cells and participate in intercellular signaling. We investigated the presence of lipid-related proteins and bioactive lipids in RBL-2H3 exosomes.
Caroline Subra, David Grand, Karine Laulagnier, Alexandre Stella, Gérard Lambeau, Michael Paillasse, Philippe De Medina, Bernard Monsarrat, Bertrand Perret, Sandrine Silvente-Poirot, Marc Poirot, Michel Record   +11 more
doaj   +1 more source

A study on the functional subunits of phospholipases A2 by enzyme immobilization [PDF]

, 1994
João Paulo Ferreira, Ram Sasisekharan, Otway Louie, Róbert Langer   +3 more
openalex   +1 more source

Phospholipase A₂Activates Hemostasis

Drug Target Insights, 2007
Phospholipases A(2) (PLA(2)) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein-mediated contact phase of coagulation. The aim of the present study was to expose citrated whole blood to PLA(2) and to quantify thrombin generation in recalcified plasma.Normal citrated blood was ...
openaire   +4 more sources

Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome

, 2021
Selcan Gültuna, Sevinç Can Sandıkçı, Hatice Kaplanoğlu, Fevzi Nuri Aydın, Funda Seher Özalp Ateş   +4 more
openalex   +2 more sources

Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes

Animal Research and One Health, EarlyView.
This study was to evaluate the role of GH in lipolysis and insulin sensitivity in bovine adipocytes and clarify the underlying mechanism. Our findings demonstrate that GH activates ERK/HSL signaling pathway, promotes lipolysis, and impairs insulin sensitivity in bovine adipocytes.
Xinxing Gao, Hao Yu, Erminio Trevisi, Cai Lin, Zhiyuan Fang, Xinwei Li, Yuxiang Song, Wenwen Gao, Lin Lei, Xiliang Du, Guowen Liu   +10 more
wiley   +1 more source

Phospholipid Signaling in Crop Plants: A Field to Explore

Plants
In plant models such as Arabidopsis thaliana, phosphatidic acid (PA), a key molecule of lipid signaling, was shown not only to be involved in stress responses, but also in plant development and nutrition.
Lucas Amokrane, Igor Pokotylo, Sébastien Acket, Amélie Ducloy, Adrian Troncoso-Ponce, Jean-Luc Cacas, Eric Ruelland   +6 more
doaj   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

INHIBITORY ACTIVITY OF Murraya paniculata AGAINST MYOTOXIC PHOSPHOLIPASES A₂

Vitae, 2010
Envenomation by snakes of the genus Bothrops are a health problem in some tropical countries, not only because of the mortality but given the high percentage of physical disabilities it causes.
Tatiana LOBO E., Jaime A. PEREAÑEZ, Karol Zapata A., Pablo A. GUTIÉRREZ, Mónica LONDOÑO, Vitelbina NÚÑEZ, Benjamín A. ROJANO   +6 more
doaj