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The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery
Pharmaceutics, 2020 This review summarizes the research on phospholipids and their use for drug delivery related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that have been approved by the PRC since 2017 and are currently still ongoing or ...
Simon Drescher, Peter van Hoogevest
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Frontiers in Microbiology, 2021 The brucellae are facultative intracellular bacteria with a cell envelope rich in phosphatidylcholine (PC). PC is abundant in eukaryotes but rare in prokaryotes, and it has been proposed that Brucella uses PC to mimic eukaryotic-like features and avoid ...
Beatriz Aragón-Aranda +13 more
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Lipids of Prokaryotic Origin at the Base of Marine Food Webs
Marine Drugs, 2012 In particular niches of the marine environment, such as abyssal trenches, icy waters and hot vents, the base of the food web is composed of bacteria and archaea that have developed strategies to survive and thrive under the most extreme conditions.
Maria José Caramujo +1 more
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Phosphoinositide-mediated oligomerization of a defensin induces cell lysis
eLife, 2014 Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells.
Ivan KH Poon +13 more
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Host Fatty Acid Utilization by
mBio, 2020 Staphylococcus aureus utilizes the fatty acid (FA) kinase system to activate exogenous FAs for membrane synthesis. We developed a lipidomics workflow to determine the membrane phosphatidylglycerol (PG) molecular species synthesized by S.
Matthew W. Frank +6 more
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eLife, 2015 Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of membranes, but it is unclear which biological processes are influenced by their regulation. For example, the functions of membrane arachidonate that are independent of
Tomomi Hashidate-Yoshida +14 more
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eLife, 2015 The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo.
Xin Rong +8 more
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Identification of a lipid scrambling domain in ANO6/TMEM16F
eLife, 2015 Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets.
Kuai Yu +5 more
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Effect of dipolar-angle on phospholipid assembly [PDF]
Phys. Rev. E 95, 062703 (2017), 2016 We report the effect of lipid head-group dipole orientation on phase behaviour of phospholipid assembly. The work explains molecular-scale mechanism of ion-lipid, anesthetic-lipid interactions where reorientation of dipoles play important role in membrane potential modification. Molecular Dynamics simulations are performed to analyse structure-property
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eLife, 2015 Maintenance of energy homeostasis depends on the highly regulated storage and release of triacylglycerol primarily in adipose tissue, and excessive storage is a feature of common metabolic disorders.
David Barneda +15 more
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