Results 11 to 20 of about 300,277 (292)

GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis[S]

Journal of Lipid Research, 2010
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report the further characterization of the two recently identified microsomal GPAT3
Dandan Shan, Jian-liang Li, Leeying Wu, Dongmei Li, Jonathan Hurov, James F. Tobin, Ruth E. Gimeno, Jingsong Cao   +7 more
doaj   +1 more source

Phospholipid signaling

Cell, 1995
Ten years ago, describing what is new in phospholipid signaling in ten pages of Cell would have been easy; it would have been essentially a summary of the phospho-inositidase C (PIC) story: phosphatidylinositol(4,5)bisphos-phate (Ptdlns(4,5)P2) hydrolysis to inositiol(1,4,5)trisphos-phate (Ins(1",4,5)P3), with the synergistic action of Ca 2÷(mobilized ...
Divecha, Nullin, Irvine, Robin F.
openaire   +3 more sources

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6−/− mice

Journal of Lipid Research, 2008
Elucidation of the metabolic pathways of triacylglycerol (TAG) synthesis is critical to the understanding of chronic metabolic disorders such as obesity, cardiovascular disease, and diabetes.
Cynthia A. Nagle, Laurent Vergnes, Hendrik DeJong, Shuli Wang, Tal M. Lewin, Karen Reue, Rosalind A. Coleman   +6 more
doaj   +1 more source

Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay II: Effect of divalent metal ions and mucin

ADMET and DMPK, 2020
The bioavailability of tetracyclines is markedly decreased when co-administered with antacids, milk, or food containing Ca2+. Previously, it was suggested that the effective intestinal permeation of tetracycline (TC) was decreased due to Ca2+ linked ...
Sachika Yamauchi, Daisuke Inoue, Kiyohiko Sugano   +2 more
doaj   +1 more source

Role of lipids in the structure and function of biological membranes

Journal of Lipid Research, 1966
The concept of biological membranes as vesicular or tubular continua built up of nesting repeating units has been systematically explored and some of the relevant experimental work has been assembled.
David E. Green, Alexander Tzagoloff
doaj   +1 more source

Comparative Study of Lipid and Fatty Acid Profile in Liver Tissues of Male and Female Silurus triostegus During the Catching Seasons

Aquatic Sciences and Engineering, 2021
In this study, seasonal variations of total fatty acid (FA), phospholipid (PL) and triacylglycerol (TAG) compositions in liver tissues of catfish (Silurus triostegus) were investigated. Samples of S. triostegus were obtained from Atatürk Dam Lake, Turkey,
Semra Kaçar, Mehmet Başhan
doaj   +1 more source

Phospholipid flippases [PDF]

FEBS Letters, 1988
Protein mediated phospholipid translocation through membranes has been observed in rat liver endoplasmic reticulum and in the plasma membrane of erythrocytes as well as in a few other cell membranes. Lipid translocation in plasma membranes is ATP dependent and selectively accumulates aminophospholipids on the inner monolayers.
openaire   +2 more sources

Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

eLife, 2014
Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells.
Ivan KH Poon, Amy A Baxter, Fung T Lay, Grant D Mills, Christopher G Adda, Jennifer AE Payne, Thanh Kha Phan, Gemma F Ryan, Julie A White, Prem K Veneer, Nicole L van der Weerden, Marilyn A Anderson, Marc Kvansakul, Mark D Hulett   +13 more
doaj   +1 more source

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

eLife, 2015
Maintenance of energy homeostasis depends on the highly regulated storage and release of triacylglycerol primarily in adipose tissue, and excessive storage is a feature of common metabolic disorders.
David Barneda, Joan Planas-Iglesias, Maria L Gaspar, Dariush Mohammadyani, Sunil Prasannan, Dirk Dormann, Gil-Soo Han, Stephen A Jesch, George M Carman, Valerian Kagan, Malcolm G Parker, Nicholas T Ktistakis, Judith Klein-Seetharaman, Ann M Dixon, Susan A Henry, Mark Christian   +15 more
doaj   +1 more source

Phospholipid Scramblases [PDF]

Lipid Insights, 2015
The distribution of phospholipid types between the two leaflets of a membrane bilayer is a controlled feature of membrane structure. One of the two membrane catalytic activities governing this distribution randomizes the composition of the two leaflets–-the phospholipid scramblases.
openaire   +2 more sources