Results 31 to 40 of about 565,738 (381)
Opsin Is a Phospholipid Flippase [PDF]
Current Biology, 2011 Polar lipids must flip-flop rapidly across biological membranes to sustain cellular life [1, 2], but flipping is energetically costly [3] and its intrinsic rate is low. To overcome this problem, cells have membrane proteins that function as lipid transporters (flippases) to accelerate flipping to a physiologically relevant rate.
Sakmar, TP +9 more
openaire +5 more sources
Hydrophobic cis-platinum complexes efficiently incorporated into liposomes [PDF]
, 1992 The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies.
Khokhar, Abdul R. +2 more
core +3 more sources
Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell penetrating peptides [PDF]
, 2009 Recent molecular dynamics simulations (Herce and Garcia, PNAS, 104: 20805 (2007)) have suggested that the arginine-rich HIV Tat peptides might be able to translocate by destabilizing and inducing transient pores in phospholipid bilayers.
Enrique, N. +7 more
core +3 more sources
P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas
Frontiers in Physiology, 2016 P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids across cell membranes. This generates and maintains membrane lipid asymmetry, a property essential for a wide variety of cellular processes such as vesicle ...
J. Andersen +5 more
semanticscholar +1 more source
Journal of Lipid Research, 2022 Advanced liver diseases account for approximately 2 million deaths annually worldwide. Roughly, half of liver disease-associated deaths arise from complications of cirrhosis and the other half driven by viral hepatitis and hepatocellular carcinoma ...
Venkateshwari Varadharajan +2 more
doaj
Phospholipid signaling in innate immune cells.
Journal of Clinical Investigation, 2018 Phospholipids comprise a large body of lipids that define cells and organelles by forming membrane structures. Importantly, their complex metabolism represents a highly controlled cellular signaling network that is essential for mounting an effective ...
V. O’Donnell, J. Rossjohn, M. Wakelam
semanticscholar +1 more source
FEBS Letters, 1988 Protein mediated phospholipid translocation through membranes has been observed in rat liver endoplasmic reticulum and in the plasma membrane of erythrocytes as well as in a few other cell membranes. Lipid translocation in plasma membranes is ATP dependent and selectively accumulates aminophospholipids on the inner monolayers.
openaire +2 more sources
Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes [PDF]
, 2015 The composition of the mitochondrial membrane is important for its architecture and proper function. Mitochondria depend on a tightly regulated supply of phospholipid via intra-mitochondrial synthesis and by direct import from the endoplasmic reticulum ...
Abid Ali, F +9 more
core +4 more sources
Single-molecule analysis of phospholipid scrambling by TMEM16F
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Membrane proteins that translocate various compounds across biological membranes play important roles in maintaining intracellular homeostasis in cells.
R. Watanabe +3 more
semanticscholar +1 more source
Phospholipid Scramblases [PDF]
Lipid Insights, 2015 The distribution of phospholipid types between the two leaflets of a membrane bilayer is a controlled feature of membrane structure. One of the two membrane catalytic activities governing this distribution randomizes the composition of the two leaflets–-the phospholipid scramblases.
openaire +2 more sources