Results 51 to 60 of about 336,810 (311)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer’s Disease

open access: yesFrontiers in Physiology, 2013
Not all of the mysteries of life lie in our genetic code. Some can be found buried in our membranes. These shells of fat, sculpted in the central nervous system into the cellular (and subcellular) boundaries of neurons and glia, are themselves complex ...
Steffany A L Bennett   +11 more
doaj   +1 more source

Ethosomes and their monotonous effects on Skin cancer disruption

open access: yesFrontiers in Nanotechnology, 2023
Skin cancer is one of the most prominent diseases, affecting all continents worldwide, and has shown a significant rise in mortality and prevalence. Conventional therapy, including chemotherapy and surgery, has a few drawbacks.
Prafull Shinde   +2 more
doaj   +1 more source

Studies on the Separation of Phospholipid from Egg Yolk [PDF]

open access: yes, 1988
P(論文)Lipoprotein and water-soluble proteins were separated from egg yolk with dextransulfate. 99.97% of the lipids were precipitated by this treatment. SDS-PAGE showed the presense of livetin in the supernatant.
筒井, 知己   +5 more
core  

Phospholipid-Mimetic Aggregation-Induced Emission Luminogens for Specific Elimination of Gram-Positive and Gram-Negative Bacteria

open access: yes, 2023
Precise elimination of both Gram-positive and Gram-negative bacteria greatly contributes to the fight against bacterial infection but remains challenging.
Jianxing Wang (1594642)   +4 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

The effect of desiccation on viability and membrane lipid composition of Acer pseudoplatanus seeds

open access: yesActa Societatis Botanicorum Poloniae, 2014
The viability of desiccation-intolerant sycamore (Acer pseudoplatanus L.) seeds during desiccation was investigated by tetrazolium and by a germinability test, together with membrane permeability and membrane phospholipid composition.
Stanisława Pukacka, Anna Czubak
doaj   +1 more source

Effects of Cooling Rate and Emulsifier Combination on the Colloidal Stability of Crystalline Dispersions Stabilized by Phospholipids and β-Lactoglobulin

open access: yesColloids and Interfaces, 2023
A lot of applications for (semi-)crystalline triacylglycerol (TAG)-in-water dispersions exist in the life science and pharmaceutical industries.
Jasmin Reiner   +3 more
doaj   +1 more source

Phospholipid-Tailored Titanium Carbide Nanosheets as a Novel Fluorescent Nanoprobe for Activity Assay and Imaging of Phospholipase D

open access: yes, 2018
As one of the emerging inorganic graphene analogues, two-dimensional titanium carbide (Ti3C2) nanosheets have attracted extensive attention in recent years because of their remarkable structural and electronic properties.
Yan Huang (46805)   +6 more
core   +1 more source

Investigation of the mechanism of fenfluramine-induced pulmonary phospholipidosis in the rat lung model [PDF]

open access: yes, 1993
Magister Pharmaceuticae - MPharmThe aim of this study was to investigate the mechanism of fenfluramine-induced pulmonary phospholipidosis, by comparing the profile and levels of induced phospholipids in the rat and the mode of phospholipase inactivation,
Hassan, Mogamat Shafick
core   +1 more source

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