Results 11 to 20 of about 19,090 (263)

Structural Insights into Protein Regulation by Phosphorylation and Substrate Recognition of Protein Kinases/Phosphatases

open access: yesLife, 2021
Protein phosphorylation is one of the most widely observed and important post-translational modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each of which covalently attaches a phosphate group to an amino acid side ...
Seung-Hyeon Seok
doaj   +1 more source

Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Protein phosphorylation and dephosphorylation are increasingly recognized as important processes for regulating multiple physiological mechanisms.
Alma Reyna Escalona-Montaño   +10 more
doaj   +1 more source

Quantitative Phosphoproteomic Analysis Provides Insights into the Sodium Bicarbonate Responsiveness of Glycine max

open access: yesBiomolecules, 2023
Sodium bicarbonate stress caused by NaHCO3 is one of the most severe abiotic stresses affecting agricultural production worldwide. However, little attention has been given to the molecular mechanisms underlying plant responses to sodium bicarbonate ...
Qiang Li   +7 more
doaj   +1 more source

Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification

open access: yesMolecular Systems Biology, 2023
Phosphoprotein phosphatases (PPPs) regulate major signaling pathways, but the determinants of phosphatase specificity are poorly understood. This is because methods to investigate this at scale are lacking.
Jamin B Hein   +10 more
doaj   +1 more source

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

open access: yesNature Communications, 2020
The substrate specificity of phosphoprotein phosphatases PP1 and PP2A depends on their catalytic and regulatory subunits. Using proteomics approaches, the authors here provide insights into the sequence specificity of the catalytic subunits and their ...
Bernhard Hoermann   +11 more
doaj   +1 more source

Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases

open access: yesToxins, 2023
Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, and terrestrial ecosystems.
Galina Nugumanova   +4 more
doaj   +1 more source

Genetic Encoding of Pentafluorophosphato-Phenylalanine Provides PF<sub>5</sub>-Proteins as Phosphoprotein Mimetics. [PDF]

open access: yesAngew Chem Int Ed Engl
Genetic code expansion with a unique hyper‐fluorinated phosphotyrosine analog. In this work, we successfully incorporated the unnatural amino acid pentafluorophosphato‐difluoromethyl‐phenylalanine, carrying seven fluorine atoms and a permanent negative charge into three different proteins via the use of mutated orthogonal aminoacyl‐tRNA synthetases ...
Ambros AM   +10 more
europepmc   +2 more sources

Isotopically Dimethyl Labeling-Based Quantitative Proteomic Analysis of Phosphoproteomes of Soybean Cultivars

open access: yesBiomolecules, 2021
Isotopically dimethyl labeling was applied in a quantitative post-translational modification (PTM) proteomic study of phosphoproteomic changes in the drought responses of two contrasting soybean cultivars.
Atieh Moradi   +12 more
doaj   +1 more source

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