Results 31 to 40 of about 29,356 (170)

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source

Technological Innovations and Applications of Spatial Transcriptomics in Livestock and Poultry Research

Animal Research and One Health, EarlyView.
The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang, Ao Guo, Lin Zhang, Shengru Wu, Juan Du, Taiyong Yu   +5 more
wiley   +1 more source

Major Causes of Rabies Outbreak in Pastoral Areas of the Somali Region and Importance of the One Health Approach

Animal Research and One Health, EarlyView.
Rabies Transmission and Control in the Somali Region. Introduction: Rabies is a fatal zoonotic disease caused by the Lyssavirus, posing a significant threat to both wildlife and public health in the Somali Region of Ethiopia. Key Points: 1. Primary Hosts: Wild carnivores such as foxes, jackals, raccoons, skunks, bats, and honey badgers are the main ...
Hassan Abdi Hussein
wiley   +1 more source

In situ biomimetic materials for dentin repair

BMEMat, EarlyView.
This review primarily discusses the role and clinical application of key biomimetic materials for in situ dentin repair, providing a feasible foundation for future material and performance optimization in situ dentin regeneration. Abstract Dental defects, ranking among the most prevalent diseases globally, pose a serious threat to human health, with ...
Jingjing Deng, Siyi Ren, Xuliang Deng, Yan Wei   +3 more
wiley   +1 more source

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages

Cancer Communications, EarlyView.
Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM.
Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue   +11 more
wiley   +1 more source

Expression of phosphoproteins and amelotin in teeth

International Journal of Molecular Medicine, 2007
The organic material of our teeth consists of collagens and a number of calcium-binding phosphoproteins. Six of these phosphoproteins have recently been grouped in the family of the SIBLINGs (small integrin-binding ligand, N-linked glycoproteins), namely osteopontin, bone sialoprotein, dentin matrix protein (DMP1), dentin sialophosphoprotein (DSPP ...
Lang, NP, Schild, C, Taeschler, S, Trueb, B   +3 more
openaire   +5 more sources

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

Design Principles Of Inorganic‐Protein Hybrid Materials for Biomedicine

Exploration, EarlyView.
Inorganic protein hybrid materials (IPHMs) due to editable structure present unrivalled potential at the intersection of synthetic biology and materials science. The synthesis of IPHMs with a high degree of biosafety from bioactive units represents a shift in material design and synthesis.
Hao Liu, Xiaohui Liu, Hui Jiang, Xuemei Wang   +3 more
wiley   +1 more source