Results 51 to 60 of about 37,055 (269)

Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolismResearch in context

EBioMedicine, 2019
Background: Meningioma is the most frequent primary intracranial tumour. Surgical resection remains the main therapeutic option as pharmacological intervention is hampered by poor knowledge of their proteomic signature.
Jemma Dunn, Sara Ferluga, Vikram Sharma, Matthias Futschik, David A. Hilton, Claire L. Adams, Edwin Lasonder, C. Oliver Hanemann   +7 more
doaj   +1 more source

Human Parainfluenza Virus 3 Phosphoprotein Is a Tetramer and Shares Structural and Interaction Features with Ebola Phosphoprotein VP35

Biomolecules, 2021
The human parainfluenza virus 3 (HPIV3) poses a risk for pneumonia development in young children and immunocompromised patients. To investigate mechanisms of HPIV3 pathogenesis, we characterized the association state and host protein interactions of ...
Joaquin Rodriguez Galvan, Brianna Donner, Cat Hoang Veseley, Patrick Reardon, Heather M. Forsythe, Jesse Howe, Gretchen Fujimura, Elisar Barbar   +7 more
doaj   +1 more source

Specific Enrichment of Phosphoproteins Using Functionalized Multivalent Nanoparticles

, 2016
Analysis of protein phosphorylation remains a significant challenge due to the low abundance of phosphoproteins and the low stoichiometry of phosphorylation, which requires effective enrichment of phosphoproteins. Here we have developed superparamagnetic
Song Jin (642035), Serife Ayaz-Guner (1548511), Zachery R. Gregorich (1649602), Wenxuan Cai (1649599), Ying Ge (175278), Santosh G. Valeja (1329417), Leekyoung Hwang (1376205)   +6 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

List of identified phosphoproteins.

, 2015
Phosphorylated proteins, peptides and residues (phosphosites) identified by mass spectrometry in protein extracts from young Arabidopsis seedlings after rubisco depletion, IMAC enrichment and 2-DE separation of phosphoproteins.
Andrew R. S. Ross (767634), Uma K. Aryal (596121), Joan E. Krochko (52333)   +2 more
core   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Gingival Enlargement Associated with Orthodontics Appliance Increases Protein Carbonylation and Alters Phosphorylation of Salivary Proteome

Dentistry Journal
Gingival enlargement is a common clinical sign in the gingival diseases associated with orthodontic treatment. Its biological mechanisms are not completely understood; nevertheless, the biochemical changes associated with these inflammatory and ...
Zulieth Lopez Arrieta, Erika Rodríguez-Cavallo, Darío Méndez-Cuadro   +2 more
doaj   +1 more source

Integrative features of the yeast phosphoproteome and protein-protein interaction map. [PDF]

PLoS Computational Biology, 2011
Following recent advances in high-throughput mass spectrometry (MS)-based proteomics, the numbers of identified phosphoproteins and their phosphosites have greatly increased in a wide variety of organisms.
Nozomu Yachie, Rintaro Saito, Naoyuki Sugiyama, Masaru Tomita, Yasushi Ishihama   +4 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Biosynthesis of Phosphoprotein in the Frog

Experimental Biology and Medicine, 1958
SummaryIntraperitoneal administration of radioactive phosphorus to Rana esculenta resulted in an appreciable incorporation of the isotope in the phosphoprotein fraction of liver and very much less in the corresponding fraction of ovary. The presence, in liver, of a metabolically active phosphopeptide, was demonstrated.
K S, SAMPATH KUMAR, T A, SUNDARARAJAN, P S, SARMA   +2 more
openaire   +2 more sources