Results 31 to 40 of about 37,055 (269)

Phosphoproteome Analysis Using Two-Dimensional Electrophoresis Coupled with Chemical Dephosphorylation

Foods, 2022
Protein phosphorylation is a reversible post-translational modification (PTM) with major regulatory roles in many cellular processes. However, the analysis of phosphoproteins remains the most challenging barrier in the prevailing proteome research ...
Raquel Rodríguez-Vázquez, Daniel Mouzo, Carlos Zapata   +2 more
doaj   +1 more source

Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease

Renal Failure, 2023
Objectives Subfornical organ (SFO) is vital in chronic kidney disease (CKD) progression caused by high salt levels. The current study investigated the effects of high salt on phosphoproteomic changes in SFO in CKD rats.Methods 5/6 nephrectomized rats ...
Xin Wang, Huizhen Wang, Jiawen Li, Lanying Li, Yifan Wang, Aiqing Li   +5 more
doaj   +1 more source

Phosphoproteins regulated by heat stress in rice leaves [PDF]

, 2011
Background High temperature is a critical abiotic stress that reduces crop yield and quality. Rice (Oryza sativa L.) plants remodel their proteomes in response to high temperature stress.
Yongfei Wang, Qiaobin Yang, Wang Yongfei, Huaqin He, Wenfeng Zhang, Yuqin Ke, Xinhai Chen, Zhang Wenfeng, Ke Yuqin, Zhang Baoqian, Zhou Jiechao, Yang Qiaobin, Chen Xinhai, He Huaqin, Baoqian Zhang, Jiechao Zhou   +15 more
core   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Effect of combined application of premixed bioceramic paste and diode laser in vital pulp therapy: an immunohistochemical randomized controlled split-mouth in vivo animal experiment [PDF]

Restorative Dentistry & Endodontics
Objectives This study aimed to evaluate the effect of premixed bioceramic paste (Well-Root PT; Vericom) compared to mineral trioxide aggregate (MTA) on the expression of the mineralization-related marker dentin sialoprotein (DSP) in dental pulp following
Mo’men A. Salama, Dalia M. Fayyad, Mohamed I. Rabie, Manar A. A. Selim, Mahmoud F. Ahmed   +4 more
doaj   +1 more source

Differential phosphoproteome regulation of nucleus accumbens in environmentally enriched and isolated rats in response to acute stress. [PDF]

PLoS ONE, 2013
Increasing evidence shows that stress contributes to the pathogenesis of major depressive disorder which is a severe neuropsychiatric disorder and influences over 10% of the world's population.
Xiuzhen Fan, Dingge Li, Yafang Zhang, Thomas A Green   +3 more
doaj   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Estimating the total number of phosphoproteins and phosphorylation sites in eukaryotic proteomes [PDF]

, 2017
Background: Phosphorylation is the most frequent post-translational modification made to proteins and may regulate protein activity as either a molecular digital switch or a rheostat.
Chaliotis, Anargyros, Vlastaridis, Panayotis, Van de Peer, Yves, Panayotis Vlastaridis, Pelagia Kyriakidou, Grigoris D Amoutzias, Kyriakidou, Pelagia, Stephen G Oliver, Oliver, Stephen G., Amoutzias, Grigoris D., Anargyros Chaliotis, Yves Van de Peer, Vlastaridis P., Kyriakidou P., Chaliotis A., Van de Peer Y., Oliver S.G., Amoutzias G.D., Oliver, Stephen G, Amoutzias, Grigoris D   +14 more
core   +2 more sources

Functional annotation of the significantly regulated phosphoproteins.

, 2023
(A) to (C) Volcano plots showing the significant fold changes of the phosphopeptides from RHΔpp6c strain compared with WT strain. Red and blue dots represent up-regulated (fold changes > 1.5 with P P B), and some of them have more than one differentially
Qin-Li Liang (5689277), Zhi-Wei Zhang (1771600), Xing-Quan Zhu (107159), Meng Wang (124646), Bao-Quan Fu (595114), Li-Xiu Sun (8093438), Lan-Bi Nie (5689280), Hany M. Elsheikha (6910232), Jin-Lei Wang (3535139), Ting-Ting Li (32847)   +9 more
core   +1 more source