Results 51 to 60 of about 73,329 (379)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Site-specific incorporation of phosphotyrosine using an expanded genetic code. [PDF]
, 2017 Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation.
Allison Wong +36 more
core +1 more source
Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data [PDF]
Frontiers in Plant Science, 2012 The ability of legume crops to fix atmospheric nitrogen via a symbiotic association with soil rhizobia makes them an essential component of many agricultural systems. Initiation of this symbiosis requires protein phosphorylation-mediated signaling in response to rhizobial signals named Nod factors. Medicago truncatula (Medicago) is the model system for
Christopher M. Rose +7 more
openaire +3 more sources
Biomolecules, 2021 The human parainfluenza virus 3 (HPIV3) poses a risk for pneumonia development in young children and immunocompromised patients. To investigate mechanisms of HPIV3 pathogenesis, we characterized the association state and host protein interactions of ...
Joaquin Rodriguez Galvan +7 more
doaj +1 more source
Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. [PDF]
, 1995 Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70.
Gelfand, EW +4 more
core +2 more sources
EBioMedicine, 2019 Background: Meningioma is the most frequent primary intracranial tumour. Surgical resection remains the main therapeutic option as pharmacological intervention is hampered by poor knowledge of their proteomic signature.
Jemma Dunn +7 more
doaj +1 more source
Nigericin-Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis. [PDF]
ProteomicsABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Bhushan V +5 more
europepmc +2 more sources
The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F [PDF]
, 2009 Receptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and synaptogenesis in Drosophila, but the signaling pathways in which they function are poorly defined.
Bugga, Lakshmi +2 more
core +2 more sources
ANIA:ANnotation and Integrated Analysis of the 14-3-3 interactome [PDF]
, 2014 The dimeric 14-3-3 proteins dock onto pairs of phosphorylated Ser and Thr residues on hundreds of proteins, and thereby regulate many events in mammalian cells.
Baskaran +51 more
core +3 more sources
Robust production of recombinant phosphoproteins using cell-free protein synthesis
Nature Communications, 2015 Understanding the functional and structural consequences of site-specific protein phosphorylation has remained limited by our inability to produce phosphoproteins at high yields. Here we address this limitation by developing a cell-free protein synthesis
J. Oza +9 more
semanticscholar +1 more source