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Computational Analysis of Phosphoproteomics Data in Multi‐Omics Cancer Studies [PDF]
Proteomics, 2021 Multiple types of molecular data for the same set of clinical samples are increasingly available and may be analyzed jointly in an integrative analysis to maximize comprehensive biological insight.
Connie R Jiménez
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Current Protocols in Protein Science, 2007
AbstractProtein phosphorylation is one of the most important mechanisms of regulating protein function in cells, and it plays an important role in controlling diverse biological processes, including cellular proliferation, migration, and metabolism.
Jun, Zhong +2 more
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AbstractProtein phosphorylation is one of the most important mechanisms of regulating protein function in cells, and it plays an important role in controlling diverse biological processes, including cellular proliferation, migration, and metabolism.
Jun, Zhong +2 more
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WIREs Systems Biology and Medicine, 2010
AbstractCurrent analytical protein methods show phosphorylation to be the most ubiquitous, evolutionary conserved post‐translational modification Post‐Translational Modification (PTM). The reversible and transient nature of protein phosphorylation allows signal transduction pathways to carry out diverse cellular functions.
Nurhan, Ozlu +5 more
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AbstractCurrent analytical protein methods show phosphorylation to be the most ubiquitous, evolutionary conserved post‐translational modification Post‐Translational Modification (PTM). The reversible and transient nature of protein phosphorylation allows signal transduction pathways to carry out diverse cellular functions.
Nurhan, Ozlu +5 more
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KinasePA: Phosphoproteomics data annotation using hypothesis driven kinase perturbation analysis [PDF]
Proteomics, 2016 Mass spectrometry (MS)-based quantitative phosphoproteomics has become a key approach for proteome-wide profiling of phosphorylation in tissues and cells.
David James +2 more
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Quest for the Crypto‐phosphoproteome
ChemBioChem, 2020AbstractProtein phosphorylation is one of the most studied post‐translational modifications (PTMs). Despite the remarkable advances in phosphoproteomics, a chemically less‐stable subset of the phosphosites, which we call the crypto‐phosphoproteome, has remained underexplored due to technological challenges.
Seungmin Ahn +2 more
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Analysis of the Subcellular Phosphoproteome Using a Novel Phosphoproteomic Reactor
Journal of Proteome Research, 2010Protein phosphorylation is an important post-translational modification involved in the regulation of many cellular processes. Mass spectrometry has been successfully used to identify protein phosphorylation in specific pathways and for global phosphoproteomic analysis.
Houjiang, Zhou +8 more
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Phosphoproteomics in drug discovery
Drug Discovery Today, 2014Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biological systems.
Melody K. Morris +3 more
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The phosphoproteomics data explosion
Current Opinion in Chemical Biology, 2009There are likely more than 500000 potential phosphorylation sites in a cellular proteome. This dynamic phosphorylation is under tight control of a variety of kinases and phosphatases. In recent years significant progress has been made in the large-scale analysis of these in vitro and in vivo protein phosphorylation events.
Lemeer, S.M., Heck, A.J.R.
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Phosphoproteomic Techniques and Applications
2014Phosphoproteomic analysis seeks to determine the overall level of protein phosphorylation, as a result of kinase and phosphatase activity, and determine the identity of proteins which are phosphorylated and the amino acid residues which hold the phosphate group.
Ed, Dudley, A Elizabeth, Bond
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2015
Cereals are the most important crop plant supplying staple food throughout the world. The economic importance and continued breeding of crop plants such as rice, maize, wheat, or barley require a detailed scientific understanding of adaptive and developmental processes.
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Cereals are the most important crop plant supplying staple food throughout the world. The economic importance and continued breeding of crop plants such as rice, maize, wheat, or barley require a detailed scientific understanding of adaptive and developmental processes.
openaire +2 more sources