Results 11 to 20 of about 3,489 (142)

Genome of the house fly, L., a global vector of diseases with adaptations to a septic environment [PDF]

, 2014
Background: Adult house flies, Musca domestica L., are mechanical vectors of more than 100 devastating diseases that have severe consequences for human and animal health.
Beukeboom, Leo W, Bopp, Daniel, Clark, Andrew G, Giers, Sarah D, Hediger, Monika, Jones, Andrew K, Kasai, Shinji, Leichter, Cheryl A, Li, Ming, Liu, Nannan, Meisel, Richard P, Minx, Patrick, Murphy, Terence D, Nelson, David R, Reid, William R, Rinkevich, Frank D, Robertson, Hugh M, Sackton, Timothy B, Sattelle, David B, Scott, Jeffrey G, Thibaud-Nissen, Francoise, Tomlinson, Chad, van de Zande, Louis, Walden, Kimberly, Warren, Wesley C, Wilson, Richard K   +25 more
core   +9 more sources

Development of covalent inhibitors: Principle, design, and application in cancer

MedComm – Oncology, Volume 2, Issue 4, December 2023., 2023
The noncysteine covalent inhibitors are a class of small molecule inhibitors that can bind irreversibly to their target enzymes through covalent bonding with noncysteine residues. They have shown promise as potential therapeutics for a variety of diseases, including cancer, infectious diseases, and autoimmune disorders. Examples of noncysteine covalent
Lang Zheng, Yang Li, Defa Wu, Huan Xiao, Shilong Zheng, Guan Wang, Qiu Sun   +6 more
wiley   +1 more source

Biomaterial‐Based Defenders Boost Biopharmaceuticals Efficacy for Spinal Cord Injury Treatment: A Review

Advanced Materials Interfaces, Volume 10, Issue 8, March 15, 2023., 2023
Although various types of biopharmaceuticals have presented multidimensional therapeutic effects in spinal cord injury (SCI), the rigorous microenvironment after SCI impedes their capacity. Biomaterial‐based defenders (BBDs) are designed to protect biopharmaceuticals passively or actively to reduce their inactivation and loss.
Xunqi Zhang, Jian Cao, Jiahe Wu, Jian‐Qing Gao   +3 more
wiley   +1 more source

Transcriptional responses of plants to As (V) stress [PDF]

, 2008
Background Arsenic is toxic to plants and a common environmental pollutant. There is a strong chemical similarity between arsenate [As (V)] and phosphate (Pi).
Abercrombie, Jason M., Halfhill, Matthew D., Ranjan, Priya, Rao, Murali R., Saxton, Arnold M., Stewart, Neal, Yuan, Joshua S.   +6 more
core   +5 more sources

Identifying genes associated with genetic control of color polymorphism in the pearl oyster Pinctada margaritifera var. cumingii (Linnaeus 1758) using a comparative whole genome pool‐sequencing approach

Evolutionary Applications, Volume 16, Issue 2, Page 408-427, February 2023., 2023
Abstract For hundreds of years, the color diversity of Mollusca shells has been a topic of interest for humanity. However, the genetic control underlying color expression is still poorly understood in mollusks. The pearl oyster Pinctada margaritifera is increasingly becoming a biological model to study this process due to its ability to produce a large
Pierre‐Louis Stenger, Chin‐Long Ky, Jeremie Vidal‐Dupiol, Serge Planes, Céline Reisser   +4 more
wiley   +1 more source

Integration of bioinformatics analysis and experimental validation identifies plasma exosomal miR‐103b/877‐5p/29c‐5p as diagnostic biomarkers for early lung adenocarcinoma

Cancer Medicine, Volume 11, Issue 23, Page 4411-4421, December 2022., 2022
Integration of bioinformatics analysis and experimental validation, this study provides novel insights into miRNA related networks in LUAD. Plasma exosomal hsa‐miR‐103b, hsa‐miR‐29c‐5p and hsa‐miR‐877‐5p may be used as diagnostic biomarkers for early LUAD.
Jing Wu, Zian Feng, Rui Wang, Ang Li, Hong Wang, Xiaodong He, Zuojun Shen   +6 more
wiley   +1 more source

Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy

MedComm, Volume 3, Issue 4, December 2022., 2022
Innate immune system responds to stimulus (bacteria, virus, lipopolysaccharide) firstly; nevertheless, exaggerated immune response results in a variety of inflammation‐related diseases. Epigenetic modifications including chromatin remodeling, DNA modifications, RNA modifications, Histone modifications, noncoding RNA, and regulate multiple signaling ...
Su Zhang, Yang Meng, Lian Zhou, Lei Qiu, Heping Wang, Dan Su, Bo Zhang, Kui‐Ming Chan, Junhong Han   +8 more
wiley   +1 more source

Suppression of high mobility group box 1 in B16F10 tumor does not inhibit the induction of neoantigen‐specific T cells

Cancer Science, Volume 113, Issue 12, Page 4082-4091, December 2022., 2022
We recently reported that HMGB1 showed a negative impact on anti‐tumor immunity, however, a positive role of HMGB1 in the initiation of innate and subsequent adaptive immunity has also been shown. In this study, we found that the suppression of HMGB1 in the tumor microenvironment does not inhibit the induction of neoantigen‐specific immunity.
Kayoko Waki, Miyako Ozawa, Akira Yamada
wiley   +1 more source

Upwelling‐level acidification and pH/pCO2 variability moderate effects of ocean acidification on brain gene expression in the temperate surfperch, Embiotoca jacksoni

Molecular Ecology, Volume 31, Issue 18, Page 4707-4725, September 2022., 2022
Abstract Acidification‐induced changes in neurological function have been documented in several tropical marine fishes. Here, we investigate whether similar patterns of neurological impacts are observed in a temperate Pacific fish that naturally experiences regular and often large shifts in environmental pH/pCO2.
Jason A. Toy, Kristy J. Kroeker, Cheryl A. Logan, Yuichiro Takeshita, Gary C. Longo, Giacomo Bernardi   +5 more
wiley   +1 more source

Dissolved organic phosphorus utilization by the marine bacterium Ruegeria pomeroyi DSS‐3 reveals chain length‐dependent polyphosphate degradation

Environmental Microbiology, Volume 24, Issue 5, Page 2259-2269, May 2022., 2022
Summary Dissolved organic phosphorus (DOP) is a critical nutritional resource for marine microbial communities. However, the relative bioavailability of different types of DOP, such as phosphomonoesters (P‐O‐C) and phosphoanhydrides (P‐O‐P), is poorly understood. Here we assess the utilization of these P sources by a representative bacterial copiotroph,
Jamee C. Adams, Rachel Steffen, Chau‐Wen Chou, Solange Duhamel, Julia M. Diaz   +4 more
wiley   +1 more source