Results 111 to 120 of about 38,220 (259)

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

open access: yesQuantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

open access: yes, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T.   +5 more
core   +1 more source

Synthetic, enzyme kinetic, and protein crystallographic studies of C-[béta]-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase [PDF]

open access: yes, 2016
LBK
Batta, Gyula   +11 more
core   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 9, Page 2456-2464, September 2025.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer   +2 more
wiley   +1 more source

Glikoenzim-inhibítorok előállítása = Synthesis of glycoenzyme inhibitors [PDF]

open access: yes, 2008
A szénhidrát alapú gyógyszerek kifejlesztésének egyik iránya a glikoenzimek gátlószereinek és szerkezet?hatás összefüggéseiknek (SAR) felderítése. A kutatás során glikozidázokat, amilázokat és glikogén foszforilázokat (GP) gátló cukorszármazékokat ...
Czifrák, Katalin   +5 more
core  

The P134Q Sucrose Phosphorylase: Subtle Changes in the Catalytic Properties Benefit the Production of 2‐O‐α‐Glucosyl Glycerol

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 9, Page 2465-2477, September 2025.
Production of the cosmetic ingredient 2‐α‐d‐glucosyl glycerol (2GG) by the Pro134Gln variant of sucrose phosphorylase from Bifidobacterium adolescentis is reported. The authors show with detailed characterization and hybrid kinetic modeling that the enzyme variant can improve the 2GG productivity of the biocatalytic process due to its increased ...
Alexander Sigg   +5 more
wiley   +1 more source

A β‐1,2‐glucan‐associated glycoside hydrolase family 1 β‐glucosidase from Streptomyces griseus

open access: yesProtein Science, Volume 34, Issue 9, September 2025.
Abstract β‐Glucosidases, major enzymes that release glucose from various natural compounds, are phylogenetically classified into glycoside hydrolase (GH) families. GH1 is the largest of these families. No β‐1,2‐glucan‐associated GH1 enzyme has been found, even though β‐1,2‐glucans are natural carbohydrates that are important for interaction between ...
Haruto Kumakura   +6 more
wiley   +1 more source

Uporaba celulaz v procesu plemenitenja [PDF]

open access: yes, 2015
Cellulases are enzymes that are used for the surface modifi cations of cellulosic materials primarily during fi nishing. It is a multi-component enzymatic system which hydrolyzes cellulose chains, on the surface of the fi bres, to glucose.
Pušić, Tanja   +2 more
core   +3 more sources

Relation between energy metabolism, glycolysis, noradrenaline release and duration of ischemia [PDF]

open access: yes, 1996
We studied the effect of 12-36 min of global ischemia followed by 36 min of reperfusion in Langendorff perfused rabbit hearts (n = 26). Metabolism was determined in terms of peak and total release of purines (adenosine, inosine, hypoxanthine), lactate ...
Benigno, M. (Massimo)   +5 more
core   +1 more source

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