Results 131 to 140 of about 38,432 (313)

BiGraph‐DTA: Predicting drug–target interactions of hepatoprotective agents with graph convolutional networks

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Predicting drug–target affinity (DTA) is critical for discovering and developing hepatoprotective agents that can prevent and treat liver diseases. In this study, we propose BiGraph‐DTA, a new predictive model for identifying DTA score prediction for hepatoprotective compounds by combining graph convolutional networks and bidirectional long ...
Arief Sartono, Bambang Riyanto Trilaksono, Sophi Damayanti, Anto Satriyo Nugroho, Firdayani Firdayani   +4 more
wiley   +1 more source

Mycoplasmas and cancer [PDF]

, 2014
The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan, Liekens, Sandra, Vande Voorde, Johan   +2 more
core  

Deltamethrin Resistance Mechanisms in Aedes aegypti Populations from Three French Overseas Territories Worldwide [PDF]

, 2015
BACKGROUND:Aedes aegypti is a cosmopolite mosquito, vector of arboviruses. The worldwide studies of its insecticide resistance have demonstrated a strong loss of susceptibility to pyrethroids, the major class of insecticide used for vector control ...
A Chandor-Proust, A Molina-Cruz, AF Harris, AJ Martins, AJ Martins, Amandine Guidez, AO O’Reilly, Audrey Lenhart, BJ Stevenson, C Brengues, C Strode, Carlos Robello, Clare Strode, D Baudon, DE Brackney, EP Lima, F Rousset, G Bingham, G Cheng, GP Garcia, H Kawada, H Kawada, I Dusfour, Isabelle Dusfour, J Hemingway, J Rosine, J Yanola, J Yanola, J-P David, JA Bisset, JD Thompson, Jean Issaly, JGB Linss, K Saavedra-Rodriguez, K Saavedra-Rodriguez, Laurent Guillaumot, LC Alvarez, LP Brito, M Gong, M Raymond, M Rodriguez, MB Mazzarri, MJ Klowden, MJ Paine, MW Pfaffl, N Jirakanjanakit, Pilar Zorrilla, Q Yang, R Srisawat, RCH Lee, Romain Girod, S Kasai, S Marcombe, S Marcombe, S Marcombe, V Bariami, WR Reid, WR Reid, Y Du   +58 more
core   +6 more sources

The Structure Of Phosphorylase Kinase Holoenzyme At Subnanometer Resolution, Location Of The Catalytic Subunit And The Substrate Glycogen Phosphorylase [PDF]

, 2009
Slavica Jonić, V.T. Skamnaki, Nick R. Brown, Nicolas Bischler, Nikos G. Oikonomakos, Nicolas Boisset, Louise Johnson, Catherine Vénien‐Bryan   +7 more
openalex   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Enhancing ascorbate in fruits and tubers through over‐expression of the l‐galactose pathway gene GDP‐l‐galactose phosphorylase [PDF]

, 2011
Sean Bulley, Michele Wright, Caius M. Rommens, Yan Hua, Maysoon Rassam, Kui Lin‐Wang, Christelle M. André, Di Brewster, Sakuntala Karunairetnam, Andrew C. Allan, William A. Laing   +10 more
openalex   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, Volume 16, Issue 1, Page 199-221, January 2026.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

Microfabricated Neural Biosensors for Detection of Neurotransmitters, Biomarkers, and Small Molecules: Emerging Trends on Self‐Sustained Systems and Energy Harvesting

Advanced Sensor Research, Volume 5, Issue 1, January 2026.
This paper reviews the state of the art and recent developments in thin‐film biosensors for the detection of neurotransmitters, small molecules, and biomarkers within flexible, implantable bioelectronic systems. It covers the main sensing modalities, including electrochemical, plasmonic, acoustic, and magnetic, alongside their materials, transduction ...
Massimo Mariello
wiley   +1 more source

Creation of strain – producer of bacterial purine nucleoside phosphorylase fused with human annexin A5

, 2020
A. B. Bulatovski, А. И. Зинченко   +1 more
openalex   +2 more sources