Results 61 to 70 of about 38,432 (313)

Identification of neural crest and melanoma cancer cell invasion and migration genes using high‐throughput screening and deep attention networks

Developmental Dynamics, EarlyView.
Abstract Background Cell migration and invasion are well‐coordinated in development and disease but remain poorly understood. We previously showed that the neural crest (NC) cell migratory wavefront shares a 45‐gene panel with other cell invasion phenomena.
J. C. Kasemeier‐Kulesa, S. Martina Perez, R. E. Baker, P. M. Kulesa   +3 more
wiley   +1 more source

Tricyclic Nucleobase Analogs and Their Ribosides as Substrates and Inhibitors of Purine-Nucleoside Phosphorylases III. Aminopurine Derivatives

Molecules, 2020
Etheno-derivatives of 2-aminopurine, 2-aminopurine riboside, and 7-deazaadenosine (tubercidine) were prepared and purified using standard methods. 2-Aminopurine reacted with aqueous chloroacetaldehyde to give two products, both exhibiting substrate ...
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Michał Górka, Agnieszka Bzowska, Ryszard Stolarski, Beata Wielgus-Kutrowska   +5 more
doaj   +1 more source

Functional and structural characterization of plastidic starch phosphorylase during barley endosperm development [PDF]

, 2017
The production of starch is essential for human nutrition and represents a major metabolic flux in the biosphere. The biosynthesis of starch in storage organs like barley endosperm operates via two main pathways using different substrates: starch ...
Cuesta-Seijo, Jose A., Hägglund, Per, Krucewicz, Katarzyna, Meier, Sebastian, Palcic, Monica M., Ruzanski, Christian, Svensson, Birte   +6 more
core   +2 more sources

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, EarlyView.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.

PLoS ONE, 2018
Purine nucleoside phosphorylases (PNPs) play an important role in the blood fluke parasite Schistosoma mansoni as a key enzyme of the purine salvage pathway. Here we present the structural and kinetic characterization of a new PNP isoform from S. mansoni,
Juliana Roberta Torini, Larissa Romanello, Fernanda Aparecida Heleno Batista, Vitor Hugo Balasco Serrão, Muhammad Faheem, Ana Eliza Zeraik, Louise Bird, Joanne Nettleship, Yamini Reddivari, Ray Owens, Ricardo DeMarco, Júlio César Borges, José Brandão-Neto, Humberto D'Muniz Pereira   +13 more
doaj   +1 more source

N-Acetylglucosaminidases from CAZy Family GH3 Are Really Glycoside Phosphorylases, Thereby Explaining Their Use of Histidine as an Acid/Base Catalyst in Place of Glutamic Acid*

Journal of Biological Chemistry, 2014
Background: GH3 β-N-acetylglucosaminidases atypically employ a His-Asp dyad as a catalytic acid base. Results: Enzymes from this GH3 subfamily are phosphorylases rather than hydrolases. Conclusion: Replacement of the Glu acid/base by His avoids Coulombic
S. Macdonald, M. Blaukopf, S. Withers
semanticscholar   +1 more source

Characterization of Cellobiose Phosphorylase and Cellodextrin Phosphorylase.

Journal of Applied Glycoscience, 2002
Two intracellular enzymes, cellobiose phosphorylase (CBP) and cellodextrin phosphorylase (CDP) are involved in the phosphorolytic pathway in cellulose degradation. Those enzymes are considered to be useful in syntheses of oligosaccharides because the reactions are reversible.
Motomitsu Kitaoka, Hajime Taniguchi, Kiyoshi Hayashi   +2 more
openaire   +2 more sources

A Rapid Colorimetric Method for Determining Calcium, Inorganic Phosphorus, and Zinc in Human Milk Using Clinical Laboratory Reagents

Journal of Clinical Laboratory Analysis, EarlyView.
We evaluated a colorimetric assay using clinical reagents for determining Ca, IP, and Zn in human milk. Significant correlations were observed between Ca, IP, and Zn levels determined by colorimetric assay and Ca, total P, and Zn levels determined by ICP‐AES.
Miori Tanaka, Misaki Mochida, Midori Date, Katsumi Mizuno   +3 more
wiley   +1 more source

Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]

, 2016
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P., Hofer, Anders, Pavlova, Anna, Ranjbarian, Farahnaz, Vodnala, Munender   +4 more
core   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source