Results 1 to 10 of about 937,756 (298)
Oxidative phosphorylation [PDF]
H. A. Krebs+4 more
openalex +3 more sources
Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice
Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet
Philip Cohen+4 more
doaj +1 more source
Phosphorylation of acetylhexosamines [PDF]
Abstract The phosphorylation of acetylglucosamine and acetylgalactosamine by adenosine triphosphate catalyzed by extracts of rat organs has been studied. The reaction products had the properties of acetylglucosamine 6-phosphate and acetylgalactosamine 1-phosphate, respectively. The enzymes appear to be different from other kinases.
Leloir, Luis Federico+2 more
openaire +4 more sources
Phosphorylation of caldesmon [PDF]
The phosphorylation of caldesmon was studied to determine if kinase activity reflected either an endogenous kinase or caldesmon itself. Titration of kinase activity with calmodulin yielded maximum activity at substoichiometric ratios of calmodulin/caldesmon.
David J. Hartshorne+5 more
openaire +2 more sources
The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase.
Tom D Deegan+4 more
doaj +1 more source
IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL ...
Olivia J. James+7 more
doaj +1 more source
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu+9 more
doaj +1 more source
Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy.
Liesbeth Guffens+2 more
doaj +1 more source
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Joanna R. Kelly+11 more
doaj +1 more source
In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε.
Joanna R. Kelly+11 more
doaj +1 more source