Results 1 to 10 of about 1,540,567 (369)

On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle [PDF]

, 2019
Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We consider the sequential phosphorylation and dephosphorylation of a protein
Conradi, Carsten, Feliu, Elisenda, Mincheva, Maya   +2 more
core   +3 more sources

Robust circadian clocks from coupled protein modification and transcription-translation cycles [PDF]

P Natl Acad Sci Usa (2010) vol. 107 (52) pp. 22540-5, 2010
The cyanobacterium Synechococcus elongatus uses both a protein phosphorylation cycle and a transcription-translation cycle to generate circadian rhythms that are highly robust against biochemical noise.
Baker, Clodong, D. K. Lubensky, D. Zwicker, Dekel, Ditty, Elowitz, Emberly, Ishiura, Johnson, Kageyama, Kitayama, Klumpp, Kondo, Liu, Markson, Mehra, Merrow, Mihalcescu, Miyoshi, Mori, Mori, Nakajima, Nakajima, Nishiwaki, P. R. ten Wolde, Qin, Takigawa-Imamura, Taniguchi, Tozaki, Xu, Xu, Yamaguchi, Yoda   +33 more
core   +2 more sources

Positional information readout in $Ca^{2+}$ signaling [PDF]

Phys. Rev. Lett. 123, 058102 (2019), 2019
Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target ...
Kruse, Karsten, Lipp, Peter, Wasnik, Vaibhav H.   +2 more
core   +2 more sources

Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice

Lupus Science and Medicine, 2023
Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Clara Figueras-Vadillo   +4 more
doaj   +1 more source

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

eLife, 2020
The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase.
Tom D Deegan, Progya P Mukherjee, Ryo Fujisawa, Cristian Polo Rivera, Karim Labib   +4 more
doaj   +1 more source

IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes

Nature Communications, 2021
Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL ...
Olivia J. James, Maud Vandereyken, Julia M. Marchingo, Francois Singh, Susan E. Bray, Jamie Wilson, Andrew G. Love, Mahima Swamy   +7 more
doaj   +1 more source

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota   +9 more
doaj   +1 more source

PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling

Cell Death Discovery, 2023
Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy.
Liesbeth Guffens, Rita Derua, Veerle Janssens   +2 more
doaj   +1 more source

Author Correction: The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Joanna R. Kelly, Silvia Martini, Nicola Brownlow, Dhira Joshi, Stefania Federico, Shirin Jamshidi, Svend Kjaer, Nicola Lockwood, Khondaker Miraz Rahman, Franca Fraternali, Peter J. Parker, Tanya N. Soliman   +11 more
doaj   +1 more source

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Nature Communications, 2020
In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε.
Joanna R. Kelly, Silvia Martini, Nicola Brownlow, Dhira Joshi, Stefania Federico, Shirin Jamshidi, Svend Kjaer, Nicola Lockwood, Khondaker Miraz Rahman, Franca Fraternali, Peter J. Parker, Tanya N. Soliman   +11 more
doaj   +1 more source