Results 1 to 10 of about 1,425,731 (316)

A current view on Tau protein phosphorylation in Alzheimer's disease.

Current Opinion in Neurobiology, 2021
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites.
Susanne Wegmann, J. Biernat, E. Mandelkow   +2 more
semanticscholar   +1 more source

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota   +9 more
doaj   +1 more source

PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling

Cell Death Discovery, 2023
Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy.
Liesbeth Guffens, Rita Derua, Veerle Janssens   +2 more
doaj   +1 more source

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Open Biology, 2022
Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways.
Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit   +14 more
doaj   +1 more source

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Nature Cell Biology, 2011
Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to nutrient limitation.
Joungmok Kim, M. Kundu, B. Viollet, K. Guan   +3 more
semanticscholar   +1 more source

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

Journal of Biological Chemistry, 1998
When mammalian cell cultures or mice are exposed to ionizing radiation in survivable or lethal amounts, novel mass components are found in the histone H2A region of two-dimensional gels.
E. Rogakou, D. Pilch, A. Orr, V. Ivanova, W. Bonner   +4 more
semanticscholar   +1 more source

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Cell, 2020
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop ...
Mehdi Bouhaddou, Danish Memon, Bjoern Meyer, K. White, V. Rezelj, Miguel Correa Marrero, B. Polacco, James E. Melnyk, Svenja Ulferts, Robyn M. Kaake, Jyoti Batra, Alicia L. Richards, Erica Stevenson, D. Gordon, Ajda Rojc, K. Obernier, Jacqueline M. Fabius, Margaret Soucheray, Lisa Miorin, Elena Moreno, Cassandra Koh, Q. Tran, Alexandra Hardy, R. Robinot, T. Vallet, B. Nilsson-Payant, Claudia Hernandez-Armenta, Alistair S. Dunham, Sebastian Weigang, Julian Knerr, Mayank Modak, D. Quintero, Yuan Zhou, Aurélien Dugourd, Alberto Valdeolivas, Trupti Patil, Qiongyu Li, Ruth Hüttenhain, Merve Cakir, Monita Muralidharan, Minkyu Kim, Gwendolyn M. Jang, B. Tutuncuoglu, J. Hiatt, Jeffrey Z. Guo, Jiewei Xu, Sophia Bouhaddou, Christopher J. P. Mathy, A. Gaulton, Emma J. Manners, Eloy Felix, Ying Shi, Marisa A. Goff, Jean K. Lim, Timothy Mcbride, M. C. O’Neal, Yiming Cai, Jason C. J. Chang, D. Broadhurst, Saker Klippsten, E. de Wit, A. Leach, T. Kortemme, B. Shoichet, M. Ott, J. Saez-Rodriguez, B. tenOever, R. Mullins, E. Fischer, G. Kochs, R. Grosse, A. García‐Sastre, M. Vignuzzi, J. R. Johnson, K. Shokat, D. Swaney, P. Beltrão, N. Krogan   +77 more
semanticscholar   +1 more source

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

Cell, 1997
Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood.
S. R. Datta, H. Dudek, Xu Tao, S. Masters, H. Fu, Y. Gotoh, M. Greenberg   +6 more
semanticscholar   +1 more source

Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor

Lupus Science and Medicine, 2021
Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Stephen W Wright, Vikram R Rao   +5 more
doaj   +1 more source

Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

eLife, 2022
The p97/Cdc48 ATPase and its ubiquitin receptors Ufd1-Npl4 are essential to unfold ubiquitylated proteins in many areas of eukaryotic cell biology.
Ryo Fujisawa, Cristian Polo Rivera, Karim PM Labib   +2 more
doaj   +1 more source