Results 11 to 20 of about 1,571,698 (347)
Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice
Lupus Science and Medicine, 2023 Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet
Philip Cohen +4 more
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The Complexity of Bub1 Regulation: Phosphorylation, Phosphorylation, Phosphorylation [PDF]
Cell Cycle, 2003 International ...
Vanoosthuyse, V., Hardwick, Kevin
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Phosphorylation of acetylhexosamines [PDF]
Archives of Biochemistry and Biophysics, 1958 Abstract The phosphorylation of acetylglucosamine and acetylgalactosamine by adenosine triphosphate catalyzed by extracts of rat organs has been studied. The reaction products had the properties of acetylglucosamine 6-phosphate and acetylgalactosamine 1-phosphate, respectively. The enzymes appear to be different from other kinases.
Leloir, Luis Federico +2 more
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Phosphorylation of caldesmon [PDF]
FEBS Letters, 1989 The phosphorylation of caldesmon was studied to determine if kinase activity reflected either an endogenous kinase or caldesmon itself. Titration of kinase activity with calmodulin yielded maximum activity at substoichiometric ratios of calmodulin/caldesmon.
David J. Hartshorne +5 more
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eLife, 2020 The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase.
Tom D Deegan +4 more
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IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
Nature Communications, 2021 Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL ...
Olivia J. James +7 more
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Wellcome Open Research, 2020 Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu +9 more
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Cell Death Discovery, 2023 Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy.
Liesbeth Guffens +2 more
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Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]
, 2014 The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen +5 more
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Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Joanna R. Kelly +11 more
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