PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
eLife, 2019 Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen +11 more
doaj +1 more source
Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]
, 2009 Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd +32 more
core +4 more sources
Cell Stem Cell, 2011 Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphoprotein linking cell-cycle-intrinsic or extracellular ...
Caretti G. +3 more
openaire +4 more sources
Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]
, 2014 Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro +5 more
core +1 more source
Metaphosphate: A New Phosphoryl Donor for NAD Phosphorylation
Agricultural and Biological Chemistry, 1980 A new nicotinamid adenine dinucleotide (NAD) kinase which synthesizes nicotinamid adenine dinucleotide phosphate (NADP) from NAD and metaphosphate was found in some microorganisms. The activity of this enzyme, designated tentatively as metaphosphate-dependent NAD kinase, was detected in Acetobacter, Achromobacter, Brevibacterium, Corynebacterium and ...
Ichiro Chibata +4 more
openaire +3 more sources
Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1 [PDF]
, 2013 The BRCT-domain protein Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.
Alcasabas +40 more
core +1 more source
USP45 and Spindly are part of the same complex implicated in cell migration
Scientific Reports, 2018 Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Claudia Conte +3 more
doaj +1 more source
Nature Communications, 2023 Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear.
Hipólito Nicolás Cuesta-Hernández +10 more
doaj +1 more source
A conserved phosphorylation site regulates the transcriptional function of ETHYLENE-INSENSITIVE3-like1 in tomato [PDF]
, 2011 ETHYLENE-INSENSITIVE3/ETHYLENE-INSENSITIVE3-like (EIN3/EIL) transcription factors are important downstream components of the ethylene transduction pathway known to regulate the transcription of early ethylene-responsive genes in plants.
Abel +37 more
core +2 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source