Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β\u3csub\u3e2\u3c/sub\u3e-agonist use [PDF]
, 2006 Background Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement.
Batra, Vikas +8 more
core +1 more source
Distinct phosphorylation clusters determines the signalling outcome of the free fatty acid receptor FFA4/GPR120 [PDF]
, 2016 It is established that long-chain free fatty acids including ω-3 fatty acids mediate an array of biological responses through members of the free fatty acid receptor family, which includes FFA4.
Alvarez-Curto, Elisa +7 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases
Life Science Alliance, 2023 This study shows that the endogenous NEK1 kinase and C21ORF2 form a tight complex in human cells and characterises the functional significance of the association of the two partner proteins. The NEK1 kinase controls ciliogenesis, mitosis, and DNA repair,
Mateusz Gregorczyk +15 more
doaj +1 more source
Tau phosphorylation at Alzheimer\u27s disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. [PDF]
, 2016 Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer\u27s disease (AD).
Ando, Kanae +6 more
core +1 more source
Site-specific incorporation of phosphotyrosine using an expanded genetic code. [PDF]
, 2017 Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation.
Allison Wong +36 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
eLife, 2017 Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain via ...
Atul Kumar +8 more
doaj +1 more source
Whole proteome copy number dataset in primary mouse cortical neurons
Data in Brief, 2023 The functional diversity of neurons is specified through their proteome resulting in elaborate and tightly regulated protein interaction networks and signalling that regulates neuronal processes.
Odetta Antico +2 more
doaj +1 more source
The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]
, 2002 Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Hörth, P. +5 more
core +1 more source