Results 81 to 90 of about 1,166,192 (319)

The Role of Calcium and Phosphorylation in the Activation of cPLA2 During TNF-induced Apoptosis [PDF]

, 2004
Tumor necrosis factor (TNF) is a pleotropic cytokine that mediates many inflammatory and innate immune responses. TNF also causes apoptosis in certain transformed cell lines and cells that are infected with certain viruses or intracellular bacteria ...
Draper, David William
core  

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation [PDF]

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
core   +1 more source

Metaphosphate: A New Phosphoryl Donor for NAD Phosphorylation

Agricultural and Biological Chemistry, 1980
A new nicotinamid adenine dinucleotide (NAD) kinase which synthesizes nicotinamid adenine dinucleotide phosphate (NADP) from NAD and metaphosphate was found in some microorganisms. The activity of this enzyme, designated tentatively as metaphosphate-dependent NAD kinase, was detected in Acetobacter, Achromobacter, Brevibacterium, Corynebacterium and ...
MURATA, Kousaku, UCHIDA, Tomofumi, TANI, Keiko, KATO, Jyoji, CHIBATA, Ichiro   +4 more
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1 [PDF]

, 2013
The BRCT-domain protein Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.
Christopher P Wardlaw (16171616), Ren, J-Y, Wardlaw, CP, Antony Oliver (4463038), Day, M, Jing-Yi Ren (627582), Garcia, V, Antony Carr (4561024), Du, L-L, Li-Lin Du (154264), Mathieu Rappas (67887), Carr, AM, Laurence Pearl (4462603), Pearl, LH, Oliver, AW, Valerie Garcia (155125), Rappas, M, Meng Qu (154161), Qu, M, Matthew Day (4464292)   +19 more
core   +1 more source

Protein phosphorylation in chloroplasts – a survey of phosphorylation targets [PDF]

Journal of Experimental Botany, 2016
The development of new software tools, improved mass spectrometry equipment, a suite of optimized scan types, and better-quality phosphopeptide affinity capture have paved the way for an explosion of mass spectrometry data on phosphopeptides. Because phosphoproteomics achieves good sensitivity, most studies use complete cell extracts for phosphopeptide
openaire   +2 more sources

Phosphorylation [PDF]

Cell Cycle, 2013
A characteristic feature of meiosis is that chromosome replication in S-phase is followed by two consecutive cell divisions to produce haploid cells. Orchestrated regulation of meiotic divisions is critical for proper segregation of chromosomes. Identification and characterization of proteins involved in this process is essential for our understanding ...
Gaplovska-Kysela, Katarina, Sevcovicova, Andrea   +1 more
openaire   +2 more sources

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]

, 2007
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero, Serafini, Riccardo, Riccardo Serafini, Alessandra De Robertis, Alessio Zippo, De Robertis, Alessandra, Zippo, Alessio, Oliviero, Salvatore   +7 more
core   +2 more sources

The EF-hand domain of MINDY3 is a ubiquitin and RAD23 UBL-binding domain

EMBO Reports
The MINDY family of deubiquitinases (DUBs) are exemplified by their preference for cleaving K48-linked polyubiquitin. MINDY3 is architecturally distinct from other MINDY DUBs as its catalytic domain spans the entire length of the protein except for an ...
Lee A Armstrong, Matthew R McFarland, Rachel O’Dea, Roscislaw Krutyholowa, Magdalena Gorka, Thomas Carroll, Sebastian Glatt, Yogesh Kulathu   +7 more
doaj   +1 more source