Results 81 to 90 of about 1,252,336 (318)

The EF-hand domain of MINDY3 is a ubiquitin and RAD23 UBL-binding domain

EMBO Reports
The MINDY family of deubiquitinases (DUBs) are exemplified by their preference for cleaving K48-linked polyubiquitin. MINDY3 is architecturally distinct from other MINDY DUBs as its catalytic domain spans the entire length of the protein except for an ...
Lee A Armstrong, Matthew R McFarland, Rachel O’Dea, Roscislaw Krutyholowa, Magdalena Gorka, Thomas Carroll, Sebastian Glatt, Yogesh Kulathu   +7 more
doaj   +1 more source

HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment

iScience
Summary: The SACK1D/FAM83D-CK1α complex assembles at the mitotic spindle to orchestrate proper spindle positioning and error-free progression through mitosis.
Tyrell N. Cartwright, Naveen K. Nakarakanti, Karen Dunbar, Luke J. Fulcher, Selina Bader, Nicola T. Wood, Thomas J. Macartney, Gopal P. Sapkota   +7 more
doaj   +1 more source

Metaphosphate: A New Phosphoryl Donor for NAD Phosphorylation

Agricultural and Biological Chemistry, 1980
A new nicotinamid adenine dinucleotide (NAD) kinase which synthesizes nicotinamid adenine dinucleotide phosphate (NADP) from NAD and metaphosphate was found in some microorganisms. The activity of this enzyme, designated tentatively as metaphosphate-dependent NAD kinase, was detected in Acetobacter, Achromobacter, Brevibacterium, Corynebacterium and ...
MURATA, Kousaku, UCHIDA, Tomofumi, TANI, Keiko, KATO, Jyoji, CHIBATA, Ichiro   +4 more
openaire   +2 more sources

Phosphorylation [PDF]

Cell Cycle, 2013
A characteristic feature of meiosis is that chromosome replication in S-phase is followed by two consecutive cell divisions to produce haploid cells. Orchestrated regulation of meiotic divisions is critical for proper segregation of chromosomes. Identification and characterization of proteins involved in this process is essential for our understanding ...
Gaplovska-Kysela, Katarina, Sevcovicova, Andrea   +1 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels [PDF]

, 2009
Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to
Miller, L.C., Sutherland, C., Sutherland, Calum, Gallagher, J., Miller, Lisa C., Ashford, M.L.J., Ning, K., Laidlaw, Hilary A., Watterson, Kenneth R., Sutherland, Calum; id_orcid, Laidlaw, H.A., Ning, Ke, Ashford, Michael L. J.; id_orcid, Watterson, K.R., Gallagher, Jennifer, Ashford, Michael L.J.   +15 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate [PDF]

, 2013
Cellular decision-making is driven by dynamic behaviours, such as the preparations for sunrise enabled by circadian rhythms and the choice of cell fates enabled by positive feedback.
Peter S Swain, Swain, Peter S, Bruno M. C. Martins (443175), Bruno M C Martins, Bruno M. C. Martins, Peter S. Swain, Martins, Bruno M. C., Martins, Bruno M C, Peter S. Swain (238162), Martins Bruno M. C., Swain, Peter S., Mac Gabhann, Feilim, Swain Peter S.   +12 more
core   +2 more sources

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity

Cell Reports, 2016
Ubiquitin is post-translationally modified by phosphorylation at several sites, but the consequences of these modifications are largely unknown. Here, we synthesize multi-milligram quantities of ubiquitin phosphorylated at serine 20, serine 57, and ...
Nicolas Huguenin-Dezot, Virginia De Cesare, Julien Peltier, Axel Knebel, Yosua Adi Kristaryianto, Daniel T. Rogerson, Yogesh Kulathu, Matthias Trost, Jason W. Chin   +8 more
doaj   +1 more source

Protein phosphorylation in chloroplasts – a survey of phosphorylation targets [PDF]

Journal of Experimental Botany, 2016
The development of new software tools, improved mass spectrometry equipment, a suite of optimized scan types, and better-quality phosphopeptide affinity capture have paved the way for an explosion of mass spectrometry data on phosphopeptides. Because phosphoproteomics achieves good sensitivity, most studies use complete cell extracts for phosphopeptide
openaire   +2 more sources