Journal of Lipid Research, 2021 Choline phospholipids (PLs) such as phosphatidylcholine (PC) and 1-alkyl-2-acyl-sn-glycerophosphocholine are important components for cell membranes and also serve as a source of several lipid mediators.
Yasuhiro Horibata, Hiroyuki Sugimoto
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Journal of Lipid Research, 2020 The final step of the CDP-ethanolamine pathway is catalyzed by ethanolamine phosphotransferase 1 (EPT1) and choline/EPT1 (CEPT1). These enzymes are likely involved in the transfer of ethanolamine phosphate from CDP-ethanolamine to lipid acceptors such as
Yasuhiro Horibata +2 more
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Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types [PDF]
Scientific Reports, 2017 In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Runjun D. Kumar, Ron Bose
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Aminoglycoside phosphotransferases proteins structure and mechanism [PDF]
Frontiers in Bioscience, 1999 Aminoglycoside antibiotics constitute an important class of clinically useful drugs which are imperiled by the emergence of resistant organisms. Aminoglycoside resistance in the clinics is primarily due to the presence of modifying enzymes which N-acetylate, O-adenylate or O-phosphorylate the antibiotics.
Wright, G. D., Thompson, Paul R
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Resistance phenotypes conferred by macrolide phosphotransferases [PDF]
FEMS Microbiology Letters, 2007 This study aims to compare the resistance phenotypes conferred by various genes encoding enzymes that phosphorylate erythromycin. The mph genes were cloned into Escherichia coli AG100A susceptible to macrolides and ketolides following disruption of the AcrAB pump.
Chesneau, Olivier +2 more
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Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase [PDF]
Nature CommunicationsPhospholipids are the most abundant component in lipid membranes and are essential for the structural and functional integrity of the cell. In eukaryotic cells, phospholipids are primarily synthesized de novo through the Kennedy pathway that involves ...
Jacquelyn R. Roberts +10 more
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Characterization of the Phosphotransferase from Bacillus subtilis 1101 That Is Responsible for the Biotransformation of Zearalenone [PDF]
ToxinsBacillus microorganisms play an important role in the zearalenone (ZEA) biotransformation process in natural environments. The phosphotransferase pathway in Bacillus is both widespread and relatively well conserved.
Yuzhuo Wu +8 more
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Predisposing deleterious variants in the cancer-associated human kinases in the global populations. [PDF]
PLoS ONEHuman kinases play essential and diverse roles in the cellular activities of maintaining homeostasis and growth. Genetic mutations in the genes encoding the kinases (or phosphotransferases) have been linked with various types of cancers.
Salman Ahmed Khan +6 more
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Xylitol and
Journal of Bacteriology, 1977 Albey M. Reiner
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Neurology International, 2023 Recent discoveries suggest links between abnormalities in cell morphogenesis in the brain and the functional deficiency of molecules controlling signal transduction in glial cells such as oligodendroglia.
Shoya Fukatsu +8 more
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