Results 21 to 30 of about 12,020 (216)

Late G1 Cell Cycle Molecular Pathways

MedEdPORTAL, 2008
The most critical stage of the cell cycle is the transition point in late G1 where the cell commits to initiating DNA synthesis. Multiple pathways of stimulation and inhibition converge, and it can be difficult for students to comprehend how all these ...
Dan Cushman, Robert Warren
doaj   +1 more source

Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. [PDF]

PLoS ONE, 2011
Antibiotic resistance is recognized as a growing healthcare problem. To address this issue, one strategy is to thwart the causal mechanism using an adjuvant in partner with the antibiotic.
Desiree H Fong, Bing Xiong, Jiyoung Hwang, Albert M Berghuis   +3 more
doaj   +1 more source

Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant

Antibiotics, 2022
Antimicrobials in wastewater promote the emergence of antibiotic resistance, facilitated by selective pressure and transfer of resistant genes. Enteric bacteria belonging to Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter ...
Christopher Mutuku, Szilvia Melegh, Krisztina Kovacs, Peter Urban, Eszter Virág, Reka Heninger, Robert Herczeg, Ágnes Sonnevend, Attila Gyenesei, Csaba Fekete, Zoltan Gazdag   +10 more
doaj   +1 more source

Aminoglycoside phosphotransferases proteins structure and mechanism [PDF]

Frontiers in Bioscience, 1999
Aminoglycoside antibiotics constitute an important class of clinically useful drugs which are imperiled by the emergence of resistant organisms. Aminoglycoside resistance in the clinics is primarily due to the presence of modifying enzymes which N-acetylate, O-adenylate or O-phosphorylate the antibiotics.
Wright, G. D., Thompson, Paul R
openaire   +4 more sources

Enzymes are enriched in bacterial essential genes.

PLoS ONE, 2011
Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying
Feng Gao, Randy Ren Zhang
doaj   +1 more source

Differential contributions of choline phosphotransferases CPT1 and CEPT1 to the biosynthesis of choline phospholipids

Journal of Lipid Research, 2021
Choline phospholipids (PLs) such as phosphatidylcholine (PC) and 1-alkyl-2-acyl-sn-glycerophosphocholine are important components for cell membranes and also serve as a source of several lipid mediators.
Yasuhiro Horibata, Hiroyuki Sugimoto
doaj  

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

Frontiers in Cellular and Infection Microbiology, 2013
Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity. Unfortunately, resistance in clinical isolates is pervasive, rendering many aminoglycosides ineffective.
Kun eShi, Shane J. Caldwell, Desiree H. Fong, Albert M. Berghuis, Albert M. Berghuis   +4 more
doaj   +1 more source

Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface

Scientific Reports, 2023
The ocular surface (OS) enzymes are of great interest due to their potential for novel ocular drug development. We aimed first to profile and classify the enzymes of the OS to describe major biological processes and pathways that are involved in the ...
Murat Akkurt Arslan, Françoise Brignole-Baudouin, Solenne Chardonnet, Cédric Pionneau, Frédéric Blond, Christophe Baudouin, Karima Kessal   +6 more
doaj   +1 more source

Genome-wide (ChIP-seq) identification of target genes regulated by BdbZIP10 during paraquat-induced oxidative stress

BMC Plant Biology, 2018
Background bZIP transcription factors play a significant role in many aspects of plant growth and development and also play critical regulatory roles during plant responses to various stresses.
Ruth C. Martin, Kelly Vining, James E. Dombrowski   +2 more
doaj   +1 more source

Quantum Mechanical/Molecular Mechanical Analysis of the Catalytic Mechanism of Phosphoserine Phosphatase

Molecules, 2018
Phosphoserine phosphatase (PSP), a member of the haloacid dehalogenase (HAD) superfamily that comprises the vast majority of phosphotransferases, is likely a steady-state regulator of the level of d-serine in the brain.
Dieter Krachtus, Jeremy C. Smith, Petra Imhof   +2 more
doaj   +1 more source