Results 31 to 40 of about 12,020 (216)

Association of Diet and Antimicrobial Resistance in Healthy U.S. Adults

open access: yesmBio, 2022
Antimicrobial resistance (AMR) represents a significant source of morbidity and mortality worldwide, with expectations that AMR-associated consequences will continue to worsen throughout the coming decades.
Andrew Oliver   +12 more
doaj   +1 more source

Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. [PDF]

open access: yesPLoS ONE, 2009
BACKGROUND:Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system ...
Swati C Chauhan, Rentala Madhubala
doaj   +1 more source

AMINOGLYCOSIDE RESISTANCE GENES IN Pseudomonas aeruginosa ISOLATES FROM CUMANA, VENEZUELA

open access: yesRevista do Instituto de Medicina Tropical de São Paulo, 2016
The enzymatic modification of aminoglycosides by aminoglycoside-acetyltransferases (AAC), aminoglycoside-adenyltransferases (AAD), and aminoglycoside-phosphotransferases (APH), is the most common resistance mechanism in P.
Bertinellys TEIXEIRA   +5 more
doaj   +1 more source

Engineering an Overflow‐Responsive Regulation System for Balancing Cellular Redox and Optimizing Microbial Production

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Escherichia coli accumulates acetate as a byproduct in fast growth aerobic conditions when using glucose as carbon source. This phenomenon, known as overflow metabolism, has negative impacts on cell growth and protein expression, also causes carbon loss during biosynthesis in most microbial production scenarios. In this study, we regarded the “
Jianli Zhang   +8 more
wiley   +1 more source

Amikacin: Uses, Resistance, and Prospects for Inhibition

open access: yesMolecules, 2017
Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad spectrum of bacterial infections. The primary resistance mechanism against these antibiotics is enzymatic modification by aminoglycoside-modifying enzymes that are
Maria S. Ramirez, Marcelo E. Tolmasky
doaj   +1 more source

Deciphering the Effect of Millet Type on the Structure of the Bacterial Community in an Indian Fermented Beverage

open access: yesFood Safety and Health, EarlyView.
Millet‐based fermented beverages were prepared using different millet varieties with an aim to investigate the microbial communities that develop during natural fermentation. This study revealed an abundance of lactic acid bacteria, highlighting their key role in natural fermentation.
Rishibha Gupta, Smriti Gaur
wiley   +1 more source

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types

open access: yesScientific Reports, 2017
In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Runjun D. Kumar, Ron Bose
doaj   +1 more source

A human skin microbiome reference catalog and the skin microbial landscape of plateau adults

open access: yesiMetaOmics, EarlyView.
Understanding the skin microbiome is crucial for elucidating its role in health and disease. However, comprehensive studies on the genetic and functional diversity of the skin microbiome in individuals living in extreme environments remain scarce. This work explores the unique characteristics and functional adaptations of the plateau skin microbiome ...
Yi Liu   +29 more
wiley   +1 more source

Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria

open access: yesMicrobiological Reviews, 1993
Numerous gram-negative and gram-positive bacteria take up carbohydrates through the phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS). This system transports and phosphorylates carbohydrates at the expense of PEP and is the subject of this review.
J.W. Lengeler, P W Postma, G R Jacobson
openaire   +2 more sources

The Phosphotransferase System in Solventogenic Clostridia

open access: yesMicrobial Physiology, 2015
The acetone-butanol-ethanol fermentation employing solventogenic clostridia was a major industrial process during the 20th century, but declined for economic reasons. In recent times, interest in the process has been revived due to the perceived potential of butanol as a superior biofuel.
openaire   +3 more sources

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