Results 31 to 40 of about 25,251 (292)

Late G1 Cell Cycle Molecular Pathways

MedEdPORTAL, 2008
The most critical stage of the cell cycle is the transition point in late G1 where the cell commits to initiating DNA synthesis. Multiple pathways of stimulation and inhibition converge, and it can be difficult for students to comprehend how all these ...
Dan Cushman, Robert Warren
doaj   +1 more source

Comparative Phylogenomics of Pathogenic and Nonpathogenic Species. [PDF]

, 2015
The Ascomycete Onygenales order embraces a diverse group of mammalian pathogens, including the yeast-forming dimorphic fungal pathogens Histoplasma capsulatum, Paracoccidioides spp. and Blastomyces dermatitidis, the dermatophytes Microsporum spp.
Taylor, John W, Whiston, Emily
core   +3 more sources

Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant

Antibiotics, 2022
Antimicrobials in wastewater promote the emergence of antibiotic resistance, facilitated by selective pressure and transfer of resistant genes. Enteric bacteria belonging to Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter ...
Christopher Mutuku, Szilvia Melegh, Krisztina Kovacs, Peter Urban, Eszter Virág, Reka Heninger, Robert Herczeg, Ágnes Sonnevend, Attila Gyenesei, Csaba Fekete, Zoltan Gazdag   +10 more
doaj   +1 more source

A New Family of Phosphotransferases with a P-loop Motif*

Journal of Biological Chemistry, 2002
In most Gram-positive bacteria, catabolite repression is mediated by a bifunctional enzyme, the histidine-containing protein kinase/phosphatase (HprK/P).
A. Galinier, J. Lavergne, C. Geourjon, S. Fieulaine, S. Nessler, J. Jault   +5 more
semanticscholar   +1 more source

Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. [PDF]

PLoS ONE, 2011
Antibiotic resistance is recognized as a growing healthcare problem. To address this issue, one strategy is to thwart the causal mechanism using an adjuvant in partner with the antibiotic.
Desiree H Fong, Bing Xiong, Jiyoung Hwang, Albert M Berghuis   +3 more
doaj   +1 more source

Study of the Aminoglycoside Subsistence Phenotype of Bacteria Residing in the Gut of Humans and Zoo Animals [PDF]

, 2016
Recent studies indicate that next to antibiotic resistance, bacteria are able to subsist on antibiotics as a carbon source. Here we evaluated the potential of gut bacteria from healthy human volunteers and zoo animals to subsist on antibiotics.
Gerrit eBor, Hauke eSmidt, Mark W.J. evan Passel, Mark W.J. evan Passel, Teresita De Jesus eBello Gonzalez, Tina eZuidema   +5 more
core   +5 more sources

Genome-wide (ChIP-seq) identification of target genes regulated by BdbZIP10 during paraquat-induced oxidative stress

BMC Plant Biology, 2018
Background bZIP transcription factors play a significant role in many aspects of plant growth and development and also play critical regulatory roles during plant responses to various stresses.
Ruth C. Martin, Kelly Vining, James E. Dombrowski   +2 more
doaj   +1 more source

Relating the metatranscriptome and metagenome of the human gut [PDF]

, 2014
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R., Chan, Andrew T., Ciulla, Dawn, Earl, Ashlee M., Franzosa, Eric A., Garrett, Wendy S., Gevers, Dirk, Giannoukos, Georgia, Huttenhower, Curtis, Izard, Jacques, Morgan, Xochitl C., Reyes, Joshua, Segata, Nicola, Waldron, Levi   +13 more
core   +2 more sources

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

Frontiers in Cellular and Infection Microbiology, 2013
Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity. Unfortunately, resistance in clinical isolates is pervasive, rendering many aminoglycosides ineffective.
Kun eShi, Shane J. Caldwell, Desiree H. Fong, Albert M. Berghuis, Albert M. Berghuis   +4 more
doaj   +1 more source

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline [PDF]

, 2016
Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the
Cranston, Anna, Gardner, Heidi, Jones, Glynn, Kanaan, Nicholas M., Koss, David J., Platt, Bettina   +5 more
core   +3 more sources