Results 31 to 40 of about 22,858 (260)

Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof

Angewandte Chemie, EarlyView.
PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim, Nicolás M. Morato, Prabir Saha, Pascal N. Eyimegwu, Aqeel A. Niyaz, Rui Huang, R. Graham Cooks, Ryan M. Phelan, Jared C. Lewis   +8 more
wiley   +2 more sources

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

Frontiers in Cellular and Infection Microbiology, 2013
Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity. Unfortunately, resistance in clinical isolates is pervasive, rendering many aminoglycosides ineffective.
Kun eShi, Shane J. Caldwell, Desiree H. Fong, Albert M. Berghuis, Albert M. Berghuis   +4 more
doaj   +1 more source

Genome-wide (ChIP-seq) identification of target genes regulated by BdbZIP10 during paraquat-induced oxidative stress

BMC Plant Biology, 2018
Background bZIP transcription factors play a significant role in many aspects of plant growth and development and also play critical regulatory roles during plant responses to various stresses.
Ruth C. Martin, Kelly Vining, James E. Dombrowski   +2 more
doaj   +1 more source

Hydrolysis of ATP by Aminoglycoside 3′-Phosphotransferases

Journal of Biological Chemistry, 2006
Aminoglycoside 3′-phosphotransferases (APH(3′)s) are common bacterial resistance enzymes to aminoglycoside antibiotics. These enzymes transfer the γ-phosphoryl group of ATP to the 3′-hydroxyl of the antibiotics, whereby the biological activity of the ...
Choonkeun Kim, J. Cha, Honggao Yan, S. Vakulenko, S. Mobashery   +4 more
semanticscholar   +1 more source

Association of Diet and Antimicrobial Resistance in Healthy U.S. Adults

mBio, 2022
Antimicrobial resistance (AMR) represents a significant source of morbidity and mortality worldwide, with expectations that AMR-associated consequences will continue to worsen throughout the coming decades.
Andrew Oliver, Zhengyao Xue, Yirui T. Villanueva, Blythe Durbin-Johnson, Zeynep Alkan, Diana H. Taft, Jinxin Liu, Ian Korf, Kevin D. Laugero, Charles B. Stephensen, David A. Mills, Mary E. Kable, Danielle G. Lemay   +12 more
doaj   +1 more source

Aminoglycoside 3'-phosphotransferases I and II in Pseudomonas aeruginosa.

Journal of antibiotics (Tokyo. 1968), 1975
Aminoglycoside 3'-phosphotransferases I and II in three strains of Pseudomonas aeruginosa were studied in comparison with those in two strains of R factor-carrying Escherichia coli. The strain TI-13 of P. aeruginosa produced the former and strain H-9 the
Y. Matsuhashi, M. Yagisawa, S. Kondo, T. Takeuchi, H. Umezawa   +4 more
semanticscholar   +1 more source

Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. [PDF]

PLoS ONE, 2009
BACKGROUND:Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system ...
Swati C Chauhan, Rentala Madhubala
doaj   +1 more source

Quantum Mechanical/Molecular Mechanical Analysis of the Catalytic Mechanism of Phosphoserine Phosphatase

Molecules, 2018
Phosphoserine phosphatase (PSP), a member of the haloacid dehalogenase (HAD) superfamily that comprises the vast majority of phosphotransferases, is likely a steady-state regulator of the level of d-serine in the brain.
Dieter Krachtus, Jeremy C. Smith, Petra Imhof   +2 more
doaj   +1 more source

AMINOGLYCOSIDE RESISTANCE GENES IN Pseudomonas aeruginosa ISOLATES FROM CUMANA, VENEZUELA

Revista do Instituto de Medicina Tropical de São Paulo, 2016
The enzymatic modification of aminoglycosides by aminoglycoside-acetyltransferases (AAC), aminoglycoside-adenyltransferases (AAD), and aminoglycoside-phosphotransferases (APH), is the most common resistance mechanism in P.
Bertinellys TEIXEIRA, Hectorina RODULFO, Numirin CARREÑO, Militza GUZMÁN, Elsa SALAZAR, Marcos DE DONATO   +5 more
doaj   +1 more source

Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases encoded by resistance plasmids.

Proceedings of the National Academy of Sciences of the United States of America, 1983
The DNA sequence of an aminoglycoside phosphotransferase gene (aph) from Streptomyces fradiae ATCC 10745 (a neomycin producer) was determined. The gene was localized by in vitro subcloning and insertional inactivation.
C. Thompson, G. Gray
semanticscholar   +1 more source