Results 41 to 50 of about 12,020 (216)

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, EarlyView.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source

Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids[S]

Journal of Lipid Research, 2020
The final step of the CDP-ethanolamine pathway is catalyzed by ethanolamine phosphotransferase 1 (EPT1) and choline/EPT1 (CEPT1). These enzymes are likely involved in the transfer of ethanolamine phosphate from CDP-ethanolamine to lipid acceptors such as
Yasuhiro Horibata, Hiromi Ando, Hiroyuki Sugimoto   +2 more
doaj  

Yeast Phosphoramidate-Adenosine Diphosphate Phosphotransferase [PDF]

Journal of Biological Chemistry, 1968
Abstract An enzyme, phosphoramidate-ADP phosphotransferase, has been isolated from dried bakers' yeast. We have previously shown that phosphoramide, N-phosphorylglycine, and N-phosphohistidine can act as phosphate donors. Phosphoiodohistidine was shown also to function as a phosphate donor and the enzyme was stereospecific for the l form of this ...
Henry I. Nakada, Michael J. Dowler
openaire   +2 more sources

Discovery, design, and engineering of enzymes based on molecular retrobiosynthesis

mLife, EarlyView.
Abstract Biosynthesis—a process utilizing biological systems to synthesize chemical compounds—has emerged as a revolutionary solution to 21st‐century challenges due to its environmental sustainability, scalability, and high stereoselectivity and regioselectivity.
Ancheng Chen, Xiangda Peng, Tao Shen, Liangzhen Zheng, Dong Wu, Sheng Wang   +5 more
wiley   +1 more source

Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis

FASEB BioAdvances, EarlyView.
Iron deficiency and anemia are frequent complications of inflammatory bowel disease (IBD) and patients are treated with oral iron supplements. To compare the outcome of iron‐deficiency or iron‐supplementation on the severity of inflammation, wild‐type mice were fed an iron‐deficient, iron‐adequate or iron‐supplemented diet.
Thanina Medjbeur, Ugo Sardo, Prunelle Perrier, Kevin Cormier, Maryline Roy, Anne Dumay, Léon Kautz   +6 more
wiley   +1 more source

Understanding the Bacterial Response to Mycotoxins: The Transcriptomic Analysis of Deoxynivalenol-Induced Changes in Devosia mutans 17-2-E-8

Frontiers in Pharmacology, 2019
Deoxynivalenol (DON) is a major fusarium toxin widely detected in cereal grains. The inadvertent exposure to this fungal secondary-metabolite gives rise to a myriad of adverse health effects including appetite loss, emesis, and suppression of the immune ...
Yousef I. Hassan, Jian Wei He, Dion Lepp, Ting Zhou   +3 more
doaj   +1 more source

Evans Blue Acts as a Selective Inhibitor of CaMKII‐α to Impede the Progression of TCL Identified by HTS

Cancer Science, EarlyView.
ABSTRACT T‐cell lymphoma (TCL) poses a significant challenge in clinical oncology, characterized by its aggressive behavior and resistance to conventional therapies. Despite considerable research efforts, the prognosis for TCL patients remains poor, primarily due to the lack of effective therapeutic strategies that can inhibit tumor progression and ...
Jianru Tian, Aiqin Zhang, Lansong Li, Hong Liu, Hui Jiang, Ruqi Liang   +5 more
wiley   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Measuring catalytic mechanism similarity – a new approach to study enzyme function and evolution

The FEBS Journal, EarlyView.
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Antonio J. M. Ribeiro, Ioannis G. Riziotis, Neera Borkakoti, Pedro A. Fernandes, Maria J. Ramos, Janet M. Thornton   +5 more
wiley   +1 more source

Effects of free fatty acids on the enzymic synthesis of diacyl and ether types of choline and ethanolamine phosphoglycerides

Journal of Lipid Research, 1976
Activities of ethanolaminephosphotransferases (EC 2.7.8.1) and choline phosphotransferases (EC 2.7.8.2) in microsomal fractions from brains and livers of mature rats are increased several fold by the addition of 1,2-diacyl-sn-glycerols or 1-alkyl-2-acyl ...
A Radominska-Pyrek, J Strosznajder, Z Dabrowiecki, T Chojnacki, L A Horrocks   +4 more
doaj