Results 51 to 60 of about 12,020 (216)

HIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways

ASN Neuro, 2016
Sensory neuropathies are the most common neurological complication of HIV. Of these, distal sensory polyneuropathy (DSP) is directly caused by HIV infection and characterized by length-dependent axonal degeneration of dorsal root ganglion (DRG) neurons ...
Sarah H. Berth, Nichole Mesnard-Hoaglin, Bin Wang, Hajwa Kim, Yuyu Song, Maria Sapar, Gerardo Morfini, Scott T. Brady   +7 more
doaj   +1 more source

Functional Repertoire of Antibiotic Resistance Genes in Antibiotic Manufacturing Effluents and Receiving Freshwater Sediments

Frontiers in Microbiology, 2018
Environments polluted by direct discharges of effluents from antibiotic manufacturing are important reservoirs for antibiotic resistance genes (ARGs), which could potentially be transferred to human pathogens.
Juan J. González-Plaza, Ana Šimatović, Milena Milaković, Ana Bielen, Fabienne Wichmann, Nikolina Udiković-Kolić   +5 more
doaj   +1 more source

Global identification of key genes for pollen germination in rice through high‐throughput screening and gene editing

Journal of Integrative Plant Biology, EarlyView.
A systematic examination of 107 T‐DNA insertional lines targeting 105 genes preferentially expressed in late pollen development identified 42 lines exhibiting significant deviations from expected Mendelian segregation ratios, suggesting a potential involvement in pollen viability and germination.
Eui‐Jung Kim, Woo‐Jong Hong, Yu‐Jin Kim, Eun Young Kim, Sang Dae Yun, Sunok Moon, Su‐Kyoung Lee, Soon Ki Park, Ki‐Hong Jung   +8 more
wiley   +1 more source

Converting Blastocrithidia Nonstop, a Trypanosomatid With Non‐Canonical Genetic Code, Into a Genetically‐Tractable Model

Molecular Microbiology, EarlyView.
Blastocrithidia represents a very small group of species, in which all 3 stop codons are reassigned to encode amino acids with only one of them serving a dual role of a sense and a stop codon simultaneously. Here we demonstrated for the first time that B. nonstop can be genetically modified.
Arnau Galan, Natalya Kraeva, Kristína Záhonová, Anzhelika Butenko, Alexei Yu Kostygov, Zdeněk Paris, Jiří Pergner, Claretta Bianchi, Fadel Fakih, Andreu Saura, Julius Lukeš, Vyacheslav Yurchenko   +11 more
wiley   +1 more source

Plant genetic transformation: achievements, current status and future prospects

Plant Biotechnology Journal, EarlyView.
Summary Regeneration represents a fundamental biological process wherein an organism's tissues or organs repair and replace themselves following damage or environmental stress. In plant systems, injured tree branches can regenerate adventitious buds and develop new crowns through propagation techniques like cuttings and canopy pruning, while transgenic
Peilin Wang, Huan Si, Chenhui Li, Zhongping Xu, Huiming Guo, Shuangxia Jin, Hongmei Cheng   +6 more
wiley   +1 more source

Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7

Pharmaceuticals, 2018
Since the approval of imatinib in 2001, kinase inhibitors have revolutionized cancer therapies. Inside this family of phosphotransferases, casein kinase 2 (CK2) is of great interest and numerous scaffolds have been investigated to design CK2 inhibitors ...
Abdelhamid Nacereddine, Andre Bollacke, Eszter Róka, Christelle Marminon, Zouhair Bouaziz, Ferenc Fenyvesi, Ildikó Katalin Bácskay, Joachim Jose, Florent Perret, Marc Le Borgne   +9 more
doaj   +1 more source

Synthetic photorespiratory bypass more stably increases potato yield per plant by improving photosynthesis

Plant Biotechnology Journal, EarlyView.
Summary The bioengineering of photorespiration has emerged as a key target for improving photosynthesis and crop yield. In our previous study, two photorespiratory bypasses, GOC and GCGT, were successfully established in rice, and the transgenic plants exhibited increased photosynthesis and yield.
Xiuling Lin, Yuming Long, Zhen Yao, Boran Shen, Min Lin, Xiaofen Zhong, Xiaohong Chen, Xiangyang Li, Guohui Zhu, Zhisheng Zhang, Xinxiang Peng   +10 more
wiley   +1 more source

Characterization of the Microbial Resistome in Conventional and “Raised Without Antibiotics” Beef and Dairy Production Systems

Frontiers in Microbiology, 2019
Metagenomic investigations have the potential to provide unprecedented insights into microbial ecologies, such as those relating to antimicrobial resistance (AMR).
Pablo Rovira, Tim McAllister, Steven M. Lakin, Shaun R. Cook, Enrique Doster, Noelle R. Noyes, Maggie D. Weinroth, Xiang Yang, Jennifer K. Parker, Christina Boucher, Calvin W. Booker, Dale R. Woerner, Keith E. Belk, Paul S. Morley   +13 more
doaj   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Identification of Primary Antimicrobial Resistance Drivers in Agricultural Nontyphoidal Salmonella enterica Serovars by Using Machine Learning

mSystems, 2019
Nontyphoidal Salmonella (NTS) is a leading global cause of bacterial foodborne morbidity and mortality. Our ability to treat severe NTS infections has been impaired by increasing antimicrobial resistance (AMR).
Finlay Maguire, Muhammad Attiq Rehman, Catherine Carrillo, Moussa S. Diarra, Robert G. Beiko   +4 more
doaj   +1 more source