Structures of Gas-Phase Hydrated Phosphotyrosine Revealed by Soft X-ray Action Spectroscopy. [PDF]
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Palmitoyltransferase DHHC7 mediates protein palmitoylation and is essential for sperm function through the modulation of [Ca<sup>2+</sup>]<sub>i</sub> and ROS signaling. [PDF]
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Identification of candidate gene networks affecting the number of somatic cells count and milk production in Iranian Holstein cows using Genome-wide association study. [PDF]
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A Novel Tyrosine Kinase Axis in Innate Immune Signaling. [PDF]
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The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2. [PDF]
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Deep Phosphotyrosine Proteomics by Optimization of Phosphotyrosine Enrichment and MS/MS Parameters
Journal of Proteome Research, 2016Phosphorylation is a major post-translational modification that regulates protein function, with phosphotyrosine (pY) modifications being implicated in oncogenesis. However, global profiling of pY statuses without treatment with a tyrosine phosphatase inhibitor such as pervanadate is still challenging due to the low occupancy of pY sites. In this study,
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