Results 111 to 120 of about 6,418 (224)

MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins

Nature Communications, 2019
Channelrhodopsins (ChRs) are algal light-gated ion channels widely used as optogenetic tools for manipulating neuronal activity. ChRs desensitize under continuous bright-light illumination, resulting in a significant decline of photocurrents.
Johannes Oppermann, Paul Fischer, Arita Silapetere, Bernhard Liepe, Silvia Rodriguez-Rozada, José Flores-Uribe, Enrico Schiewer, Anke Keidel, Johannes Vierock, Joel Kaufmann, Matthias Broser, Meike Luck, Franz Bartl, Peter Hildebrandt, J. Simon Wiegert, Oded Béjà, Peter Hegemann, Jonas Wietek   +17 more
doaj   +1 more source

Early Photocycle of Slr1694 Blue-Light Using Flavin Photoreceptor Unraveled through Adiabatic Excited-State Quantum Mechanical/Molecular Mechanical Dynamics

, 2019
Blue-light using flavin (BLUF) photoreceptor proteins are essential to many biological processes and are attractive candidates for use in optogenetics.
Joshua J. Goings, Sharon Hammes-Schiffer (1274832), Sharon Hammes-Schiffer, Joshua J. Goings (1754986)   +3 more
core   +1 more source

pH dependence of the photoactive yellow protein photocycle recovery reaction reveals a new late photocycle intermediate with a deprotonated chromophore

, 2009
The recovery reaction of the signaling state of photoactive yellow protein includes the following: (i) deprotonation of the p-coumaryl chromophore, (ii) refolding of the protein, and (iii) chromophore re-isomerization from the cis to the trans ...
Hendriks, J., Hellingwerf, K.J.
core   +1 more source

Deuterium Isotope Effects in the Photocycle Transitions of the Photoactive Yellow Protein

, 2008
The Photoactive Yellow Protein (PYP) from Halorhodospira halophila (formerly Ectothiorhodospira halophila) is increasingly used as a model system. As such, a thorough understanding of the photocycle of PYP is essential.
Johnny Hendriks, Ivo H. M. Van Stokkum, Klaas J. Hellingwerf Z   +2 more
core  

Controlled Reduction of the Humidity Induces a Shortcut Recovery Reaction in the Photocycle of Photoactive Yellow Protein

, 2016
The photocycle of the blue-light photoreceptor protein Photoactive Yellow Protein (PYP) was studied at reduced relative humidity (RH). Photocycle kinetics and spectra were measured in thin films of PYP in which the relative humidity was set at values ...
Michael A. van der Horst (2334394), Ivo H. M. van Stokkum (1273278), Norbert A. Dencher (2678863), Klaas J. Hellingwerf (467674)   +3 more
core   +1 more source

Spectral Characteristics of the Photocycle of Channelrhodopsin-2 and Its Implication for Channel Function

, 2008
In 2003, channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii was discovered to be a light-gated cation channel, and since that time the channel became an excellent tool to control by light neuronal cells in culture as well as in living animals with ...
Bamann, C., Kirsch, T., Nagel, G., Bamberg, E.   +3 more
core   +1 more source

Structural effects of high laser power densities on an early bacteriorhodopsin photocycle intermediate

Nature Communications
Time-resolved serial crystallography at X-ray Free Electron Lasers offers the opportunity to observe ultrafast photochemical reactions at the atomic level.
Quentin Bertrand, Przemyslaw Nogly, Eriko Nango, Demet Kekilli, Georgii Khusainov, Antonia Furrer, Daniel James, Florian Dworkowski, Petr Skopintsev, Sandra Mous, Isabelle Martiel, Per Börjesson, Giorgia Ortolani, Chia-Ying Huang, Michal Kepa, Dmitry Ozerov, Steffen Brünle, Valerie Panneels, Tomoyuki Tanaka, Rie Tanaka, Kensuke Tono, Shigeki Owada, Philip J. M. Johnson, Karol Nass, Gregor Knopp, Claudio Cirelli, Christopher Milne, Gebhard Schertler, So Iwata, Richard Neutze, Tobias Weinert, Jörg Standfuss   +31 more
doaj   +1 more source

Testing kinetic models for the bacteriorhodopsin photocycle-II. Inclusion of an O to M backreaction

, 1984
Using previously established procedures we have tested a kinetic model of bacteriorhodopsin involving a backreaction from O to M. This model is superior to the previously tested models involving only unidirectional reaction paths.
Parodi, Luis A., Bhattacharjee, Somendra M., Lozier, Richard H., Nagle, John F.   +3 more
core   +1 more source

In vivo absorption spectra of the two stable states of the Euglena photoreceptor photocycle, P. Gualtieri

, 2008
Euglena gracilis possesses a simple but sophisticated light detecting system, consisting of an eyespot formed by carotenoids globules and a photoreceptor. The photoreceptor of Euglena is characterized by optical bistability, with two stable states.
Passarelli V, Gualtieri P, Frassanito A M, Barsanti L, Vesentini N, Coltelli P, Evangelista V, Santoro F   +7 more
core  

Fast singlet excited-state deactivation pathway of flavin with a trimethoxyphenyl derivative

Scientific Reports
Incorporation of the trimethoxyphenyl group at position 7 of flavin can drastically change the photophysical properties of flavin. We show unique fast singlet 1(π,π*) excited state deactivation pathway through nonadiabatic transition to the 1(n,π ...
Stanisław Niziński, Naisargi Varma, Marek Sikorski, Tomáš Tobrman, Eva Svobodová, Radek Cibulka, Michał F. Rode, Gotard Burdzinski   +7 more
doaj   +1 more source