Results 81 to 90 of about 6,418 (224)

Effect of a bound anion on the structure and dynamics of halorhodopsin from Natronomonas pharaonis

Structural Dynamics, 2019
Active ion transport across membranes is vital to maintaining the electrochemical gradients of ions in cells and is mediated by transmembrane proteins. Halorhodopsin (HR) functions as a light-driven inward pump for chloride ions. The protein contains all-
Misao Mizuno, Yumi Shimoo, Hideki Kandori, Yasuhisa Mizutani   +3 more
doaj   +1 more source

Branching reactions in the photocycle of bacteriorhodopsin

FEBS Letters, 1978
The purple membrane of Halobacterium halobium acts as a light-driven proton pump [ 11. It contains a single protein to which a retinal is bound via a protonated Schiff-base [2,3]. This protein-retinal complex, bacteriorhodopsin (BR), undergoes a reaction cycle involving several intermediates after light absorption.
Korenstein, Rafi, Hess, Benno, Kuschmitz, Dietrich   +2 more
openaire   +2 more sources

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza, Renato W. Martins Sá, Luiza Henrique de Souza, Fernando S. Ramalho, Davi J. A. Moraes   +4 more
wiley   +1 more source

Spectroscopic Evidence for the Formation of an N Intermediate during the Photocycle of Sensory Rhodopsin II (Phoborhodopsin) from Natronobacterium pharaonis

, 2016
Sensory rhodopsin II is a seven transmembrane helical retinal protein and functions as a photoreceptor protein in negative phototaxis of halophilic archaea.
Yusuke Tateishi (2218048), Jun Tamogami (1403491), Takayuki Abe (170440), Yutaka Nakao (2218045), Masashi Unno (1294953), Takashi Kikukawa (1289667), Naoki Kamo (1403488)   +6 more
core   +1 more source

Atomistic Insight into the Role of Threonine 127 in the Functional Mechanism of Channelrhodopsin-2

Applied Sciences, 2019
Channelrhodopsins (ChRs) belong to the unique class of light-gated ion channels. The structure of channelrhodopsin-2 from Chlamydomonas reinhardtii (CrChR2) has been resolved, but the mechanistic link between light-induced isomerization of the ...
David Ehrenberg, Nils Krause, Mattia Saita, Christian Bamann, Rajiv K. Kar, Kirsten Hoffmann, Dorothea Heinrich, Igor Schapiro, Joachim Heberle, Ramona Schlesinger   +9 more
doaj   +1 more source

Channelrhodopsin ion selectivity determines mechanisms and efficacy of optogenetic defibrillation in human atria and ventricles

The Journal of Physiology, EarlyView.
Abstract figure legend A, we used in silico models of human cardiomyocytes and microelectrode recordings on transgenic zebrafish hearts to study electrophysiology during optogenetic perturbations. Specifically, we compared effects of three distinct classes of channelrhodopsins: the cation non‐selective Chlamydomonas reinhardtii channelrhodopsin‐2 (ChR2)
Sophia Ohnemus, Albert Dasí, Ahmed F. Ramadan, Joachim Greiner, Eike M. Wülfers, Matthew R. Stoyek, Linda Tillert, Johannes Vierock, T. Alexander Quinn, Peter Kohl, Patrick M. Boyle, Viviane Timmermann, Franziska Schneider‐Warme   +12 more
wiley   +1 more source

Photocycle Dynamics of the E149A Mutant of Cryptochrome 3 from Arabidopsis thaliana

, 2009
The E149A mutant of the cryDASH member cryptochrome 3 (cry3) from Arabidopsis thaliana was characterized in vitro by optical absorption and emission spectroscopic studies.
Moldt, J., Penzkofer, Alfons, Batschauer, Alfred, Zirak, Peyman, Essen, Lars-Oliver, Pokorny, R., A. Penzkofer, P. Zirak, A. Batschauer, R. Pokorny, J. Moldt, L.-O. Essen   +11 more
core   +1 more source

Theory and Procedures for Finding a Correct Kinetic Model for the Bacteriorhodopsin Photocycle

, 2016
In this paper, we present the implementation and results of new methodology based on linear algebra. The theory behind these methods is covered in detail in the Supporting Information, available electronically (Shrager and Hendler). In brief, the methods
Salil Bose (2948820), Richard W. Hendler (2532925), Richard I. Shrager (2948823)   +2 more
core   +3 more sources

Ion Channel Properties of a Cation Channelrhodopsin, Gt_CCR4

Applied Sciences, 2019
We previously reported a cation channelrhodopsin, Gt_CCR4, which is one of the 44 types of microbial rhodopsins from a cryptophyte flagellate, Guillardia theta.
Shunta Shigemura, Shoko Hososhima, Hideki Kandori, Satoshi P. Tsunoda   +3 more
doaj   +1 more source

The three‐element Windkessel parameters have empirical relations that uniquely define the mechanoenergetics of cardiac muscle shortening

The Journal of Physiology, EarlyView.
Abstract figure legend By collecting literature data across multiple species, we identified empirical relations among arterial resistance, compliance and impedance, which are the three biophysical indices used to characterise the arterial load against which the heart ejects.
Chamal Kohombakadawala, Toan Pham, Kenneth Tran, Andrew Taberner, June‐Chiew Han   +4 more
wiley   +1 more source