Results 141 to 150 of about 194,952 (354)

Single GAF Domain Phytochrome Exhibits a pH‐Dependent Shunt on the Millisecond Timescale

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
During their light‐induced photocycle, phytochromes can engage in a thermal reversion back to the initially excited state, denoted as a shunt. This study investigates a pH‐dependent shunt transition in the Pfr state of the All2699g1 phytochrome from Nostoc punctiforme using UV/Vis laser flash photolysis and kinetic modeling. The findings suggest a keto‐
Florian Trunk, Lisa Köhler, Tobias Fischer, Wolfgang Gärtner, Chen Song, Chavdar Slavov, Josef Wachtveitl   +6 more
wiley   +1 more source

A Nonlinear Model of Spatiotemporal Retinal Processing: Simulations of X and Y Retinal Ganglion Cell Behavior [PDF]

, 1993
This article describes a nonlinear model of neural processing in the vertebrate retina, comprising model photoreceptors, model push-pull bipolar cells, and model ganglion cells.
Gaudiano, Paolo
core   +1 more source

Epilepsy characteristics in patients with muscle‐eye‐brain disease: A systematic review of electroclinical features

Epileptic Disorders, EarlyView.
Abstract Background and Objectives Muscle‐Eye‐Brain disease (MEB) is a dystroglycanopathy that belongs to the congenital muscular dystrophies. Central nervous system manifestations include congenital brain abnormalities, neurodevelopmental delay, and epilepsy, making it a rare but important cause of developmental and epileptic encephalopathy.
Stefania Kalampokini, Evripidis Pityrigkas, Eleni Liouta, Georgia Pepe, Vasiliki Poulidou, Martha Spilioti, Vasilios K. Kimiskidis   +6 more
wiley   +1 more source

Retinoprotective Effects of Bilberry Anthocyanins via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms in a Visible Light-Induced Retinal Degeneration Model in Pigmented Rabbits

Molecules, 2015
Excessive visible light exposure can induce damage to retinal cells and contribute to the development or progression of age-related macular degeneration. In this study we created a model of phototoxicity in pigmented rabbits. Furthermore, we investigated
Yong Wang, Liang Zhao, Feng Lu, Xue Yang, Qianchun Deng, Baoping Ji, Fenghong Huang   +6 more
doaj   +1 more source

Linking photoreceptor excitation to changes in plant architecture.

Genes & Development, 2012
Plants sense neighbor proximity as a decrease in the ratio of red to far-red light, which triggers a series of developmental responses. In Arabidopsis, phytochrome B (PHYB) is the major sensor of shade, but PHYB excitation has not been linked directly to
Lin Li, K. Ljung, G. Breton, Robert J. Schmitz, José L. Pruneda-Paz, Christopher Cowing-Zitron, Benjamin J. Cole, Lauren J. Ivans, Ullas V. Pedmale, Hou-Sung Jung, J. Ecker, S. Kay, J. Chory   +12 more
semanticscholar   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Resveratrol Protects Photoreceptors in Mouse Models of Retinal Degeneration

Antioxidants
Photoreceptor/retinal degeneration is the major cause of blindness. Induced and inherited mouse models of retinal degeneration are valuable tools for investigating disease mechanisms and developing therapeutic interventions.
Shujuan Li, Hongwei Ma, Xi-Qin Ding
doaj   +1 more source

Fungal Gene Mutation Analysis Elucidating Photoselective Enhancement of UV-C Disinfection Efficiency Toward Spoilage Agents on Fruit Surface

Frontiers in Microbiology, 2018
Short-wave ultraviolet (UV-C) treatment represents a potent, clean and safe substitute to chemical sanitizers for fresh fruit preservation. However, the dosage requirement for microbial disinfection may have negative effects on fruit quality.
Pinkuan Zhu, Qianwen Li, Sepideh M. Azad, Yu Qi, Yiwen Wang, Yina Jiang, Ling Xu   +6 more
doaj   +1 more source

THE RENEWAL OF PHOTORECEPTOR CELL OUTER SEGMENTS

Journal of Cell Biology, 1967
The utilization of methionine-3H by retinal photoreceptor cells has been studied by radioautographic technique in the rat, mouse, and frog. In all three species, the labeled amino acid is concentrated initially in the inner segment of the cell. Within 24
R. W. Young
semanticscholar   +1 more source