Results 171 to 180 of about 101,792 (303)

Low‐contrast visual acuity versus low‐luminance visual acuity in choroideremia

Clinical and Experimental Optometry, EarlyView., 2020
Clinical relevance Choroideremia is a progressive X‐linked inherited rod‐cone dystrophy. Patients present with nyctalopia and progressive visual field loss, but visual acuity remains well preserved early on. This study showed that low‐luminance visual acuity may be a useful clinical outcome measure during earlier disease stages.
Laura J Wood, Jasleen K Jolly, Colm D Andrews, Iain R Wilson, Doron Hickey, Jasmina Cehajic‐Kapetanovic, Robert E MacLaren   +6 more
wiley   +1 more source

Beyond Sexual Selection: Natural Selection Related Camouflage and Thermoregulation Shape Sexual Color Dimorphism in Diploderma Lizards

Integrative Zoology, EarlyView.
Integrating comparative spectrometry, image analysis, and thermal modeling, we reveal that (1) females optimize crypsis via background matching, (2) males prioritize high‐contrast disruptive patterning at a significant thermoregulatory cost (reduced solar heat gain), and (3) habitat‐specific monomorphism in Diploderma slowinskii underscores ecological ...
Yuning Cao, Lin Shi, Yin Qi
wiley   +1 more source

Photostimulation improves maturation of human photoreceptors. [PDF]

Nat Commun
Celiker C, Hruba E, Kyriakou K, Dorgau B, Gambin FM, Weissova K, van Oosten E, Englmaier L, Vaskovicova N, Savage MA, Hilgen G, Sernagor E, Garanto A, Lako M, Barta T.   +14 more
europepmc   +1 more source

Multi‐Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies

Integrative Zoology, EarlyView.
Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun   +4 more
wiley   +1 more source

Dual Targeting of Galanin Receptor 3 Signaling and Redox Homeostasis Enhances Photoreceptor Survival in Retinas of <i>rd10</i> Mice. [PDF]

Antioxidants (Basel)
Azam M, Liu M, Jastrzebska B.
europepmc   +1 more source

Comparisons Between Large‐Scale Genomic Variants and SNPs in Driving Population Divergence and Local Adaptation

Integrative Zoology, EarlyView.
Candidate genes identified from SNPs, indels, and SVs exhibited limited shared genes, suggesting that diverse variant types capture complementary aspects of the adaptive landscape. Our results underscore the importance of incorporating multiple types of genomic variation to achieve a more comprehensive understanding of evolutionary processes.
Qianghui Zhu, Hongrui Lv, Yalin Cheng, Shangyu Wang, Dezhi Zhang, Yan Hao, Gang Song, Fumin Lei   +7 more
wiley   +1 more source

Long-term daily light exposure boosts human retinal organoid differentiation. [PDF]

Commun Biol
van Oosten EM, Kieboom W, Hoogendoorn ADM, Berendsen SL, Haerkens J, van der Maden MME, Hruba E, Veerman D, Bufe A, Almedawar S, van der Meer AD, Barta T, Collin RWJ, Garanto A.   +13 more
europepmc   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Exploring dose-dependent outcomes of photobiomodulation with two infrared wavelengths applied to injured Drosophila retinae. [PDF]

PLoS One
Meece M, Worthington S, Pierce L, Sikirzhytskaya M, Buschbeck EK.   +4 more
europepmc   +1 more source

The optical coherence tomography and microperimetry biomarker evaluation in patients with geographic atrophy (OMEGA) study: Geographic atrophy progression in fundus autofluorescence ‐ OMEGA report 3

Acta Ophthalmologica, EarlyView.
Abstract Purpose To measure the progression of geographic atrophy (GA) in subjects with age‐related macular degeneration (AMD) in a natural history study. Methods We analysed fundus autofluorescence (FAF) images using a semiautomatic method (RegionFinder) to quantify the GA area in a monocentric study.
Philippe Valmaggia, Georg Ansari, Nadja Inglin, Nils Schärer, Hanna Zuche, Chrysoula Gabrani, Faady Yahya, Marco Cattaneo, Kristina Pfau, Andrea Giani, Marieh Esmaeelpour, Taffeta Chingning Yamaguchi, Christian Prünte, Hendrik P. N. Scholl, Nicolas Feltgen, Leopold Schmetterer, Maximilian Pfau, Peter M. Maloca   +17 more
wiley   +1 more source