Results 31 to 40 of about 78,413 (264)

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

eLife, 2020
During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated.
Miruna Georgiana Ghinia Tegla, Diego F Buenaventura, Diana Y Kim, Cassandra Thakurdin, Kevin C Gonzalez, Mark M Emerson   +5 more
doaj   +1 more source

P2X7 Is Involved in the Mouse Retinal Degeneration via the Coordinated Actions in Different Retinal Cell Types

Antioxidants, 2023
Adenosine triphosphate (ATP) released from dying cells with high concentrations is sensed as a danger signal by the P2X7 receptor. Sodium iodate (NaIO3) is an oxidative toxic agent, and its retinal toxicity has been used as the model of dry age-related ...
Ponarulselvam Sekar, George Hsiao, Yuan-Shen Chen, Wan-Wan Lin, Chi-Ming Chan   +4 more
doaj   +1 more source

photoreceptors [PDF]

, 2018
Plasticity is a crucial aspect of neuronal physiology essential for proper development and continuous functional optimization of neurons and neural circuits.
Saari, Paulus, Esa-Ville Immonen, Roman V. Frolov, Hongxia Liu, French, Andrew S., Liu, Hongxia, Andrew S. French, Frolov, Roman V., Torkkeli, Päivi H., Paulus Saari, Immonen, Esa-Ville, Päivi H. Torkkeli   +11 more
core   +1 more source

Iroquois complex genes induce co-expression of rhodopsins in Drosophila. [PDF]

, 2008
The Drosophila eye is a mosaic that results from the stochastic distribution of two ommatidial subtypes. Pale and yellow ommatidia can be distinguished by the expression of distinct rhodopsins and other pigments in their inner photoreceptors (R7 and R8),
Mathias F Wernet, Desplan, C, Pichaud, F, Daniel Vasiliauskas, Vasiliauskas Daniel, Pichaud Franck, Celik, A, Cook Tiffany A, Vasiliauskas, D, Cook, TA, Mazzoni Esteban O, Franck Pichaud, Johnston, RJ, Wernet Mathias F, Esteban O Mazzoni, Mazzoni, EO, Arzu Celik, Robert J Johnston, Tiffany A Cook, Johnston Robert J, Claude Desplan, Celik Arzu, Desplan Claude, Wernet, MF   +23 more
core   +1 more source

Discordant Responses to MAPK Pathway Stimulation Include Axonal Growths in Adult Drosophila Photoreceptors

Frontiers in Molecular Neuroscience, 2018
Wallenda (WND) is the Drosophila member of a conserved family of dual leucine-zipper kinases (DLK) active in both neuronal regeneration and degeneration.
Kirk L. Mecklenburg, Forrest P. Weghorst, Stephanie A. Freed, Joseph E. O’Tousa   +3 more
doaj   +1 more source

Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration

Molecular Therapy: Methods & Clinical Development, 2021
Photoreceptor loss is the principal cause of blindness in retinal degenerative diseases (RDDs). Whereas some therapies exist for early stages of RDDs, no effective treatment is currently available for later stages, and once photoreceptors are lost, the ...
Anna Salas, Anna Duarri, Laura Fontrodona, Diana Mora Ramírez, Anna Badia, Helena Isla-Magrané, Barbara Ferreira-de-Souza, Miguel Ángel Zapata, Ángel Raya, Anna Veiga, José García-Arumí   +10 more
doaj   +1 more source

Differentiation of photoreceptors

, 2021
Chapter 7 discusses how photoreceptors and other cells found in the retina of the vertebrate eye or in the pineal body differentiate. These cell types do not develop from cranial placodes but from the neural tube.
Schlosser, Gerhard
core   +1 more source

Genetic and Molecular Characterization of a Cryptochrome from the Filamentous Fungus Neurospora crassa [PDF]

, 2010
In plants and animals, cryptochromes function as either photoreceptors or circadian clock components. We have examined the cryptochrome from the filamentous fungus Neurospora crassa and demonstrate that Neurospora cry encodes a DASH-type cryptochrome ...
Belden, William J.,, Jennifer J. Loros, Roenneberg, Till, Merrow, Martha,, Froehlich, Allan C., Dunlap, Jay C., Allan C. Froehlich, Merrow, Martha, Till Roenneberg, Loros, Jennifer J.,, Dunlap, Jay C.,, William J. Belden, Loros, Jennifer J., Roenneberg, Till,, Belden, William J., Cornelia Madeti, Madeti, Cornelia,, Froehlich, Allan C.,, Martha Merrow, Chen-hui Chen, Chen, Chen-Hui,, Madeti, Cornelia, Chen, Chen-Hui, Jay C. Dunlap   +23 more
core   +2 more sources

Differential Responses of Neural Retina Progenitor Populations to Chronic Hyperglycemia

Cells, 2021
Diabetic retinopathy is a frequent complication of longstanding diabetes, which comprises a complex interplay of microvascular abnormalities and neurodegeneration.
Nicole Schmitner, Christina Recheis, Jakob Thönig, Robin A. Kimmel   +3 more
doaj   +1 more source

Limitations and Promise of Retinal Tissue From Human Pluripotent Stem Cells for Developing Therapies of Blindness

Frontiers in Cellular Neuroscience, 2020
The self-formation of retinal tissue from pluripotent stem cells generated a tremendous promise for developing new therapies of retinal degenerative diseases, which previously seemed unattainable.
Ratnesh K. Singh, Igor O. Nasonkin
doaj   +1 more source