Results 41 to 50 of about 108,777 (309)

Synaptic Remodeling in the Cone Pathway After Early Postnatal Horizontal Cell Ablation

Frontiers in Cellular Neuroscience, 2021
The first synapse of the visual pathway is formed by photoreceptors, horizontal cells and bipolar cells. While ON bipolar cells invaginate into the photoreceptor terminal and form synaptic triads together with invaginating horizontal cell processes, OFF ...
Lena Nemitz, Karin Dedek, Karin Dedek, Ulrike Janssen-Bienhold, Ulrike Janssen-Bienhold   +4 more
doaj   +1 more source

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]

, 2019
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana, Asfour, Hani Z., Ding, Yuchun, Doherty, Mary, Dorgau, Birthe, Felemban, Majed, Hallam, Dean, Hilgen, Gerrit, Hunt, Nicola Claire, Kiening, Martin, Krasnogor, Natalio, Lako, Majlinda, Sernagor, Evelyne, White, Kathryn, Whitfield, Phil, Zerti, Darin   +15 more
core   +2 more sources

A Defective Crosstalk Between Neurons and Müller Glial Cells in the rd1 Retina Impairs the Regenerative Potential of Glial Stem Cells

Frontiers in Cellular Neuroscience, 2019
Müller glial cells (MGC) are stem cells in the retina. Although their regenerative capacity is very low in mammals, the use of MGC as stem cells to regenerate photoreceptors (PHRs) during retina degenerations, such as in retinitis pigmentosa, is being ...
Yanel A. Volonté, Harmonie Vallese-Maurizi, Marcos J. Dibo, Victoria B. Ayala-Peña, Andrés Garelli, Samanta R. Zanetti, Axel Turpaud, Cheryl Mae Craft, Cheryl Mae Craft, Nora P. Rotstein, Luis E. Politi, Olga L. German   +11 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina

Stem Cell Research & Therapy
Background The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic cargo.
Margaret T. Ho, Kotoe Kawai, Dhana Abdo, Lacrimioara Comanita, Arturo Ortin-Martinez, Yui Ueno, Emily Tsao, Azam Rastgar-Moghadam, Chang Xue, Hong Cui, Valerie A. Wallace, Molly S. Shoichet   +11 more
doaj   +1 more source

Preliminary study on electrophysiological changes after cellular autograft in age-related macular degeneration [PDF]

, 2014
Background: Evolving atrophic macular degeneration represents at least 80% of all macular degenerations and is currently without a standardized care. Autologous fat transplantation (AFT) efficacy was demonstrated by several studies, since these cells are
C., Limoli, M. U., Morales, Nebbioso, Marcella, P. G., Limoli, Vingolo, Enzo Maria   +4 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

High-Blue/Low-Red Mixed Light Modulates Photoperiodic Flowering in Chrysanthemum via Photoreceptor and Sugar Pathways

Plants
Chrysanthemum (Chrysanthemum morifolium Ramat.), a typical short-day plant (SDP), relies on photoperiod and light quality signals to regulate flowering and growth.
Jingli Yang, Zhengyang Cheng, Jinnan Song, Byoung Ryong Jeong   +3 more
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Age-dependent changes of monocarboxylate transporter 8 availability in the postnatal murine retina

Frontiers in Cellular Neuroscience, 2016
The thyroid hormones (TH) triiodothyronine (T3) and its prohormone thyroxine (T4) are crucial for retinal development and function, and increasing evidence points at TH dysregulation as a cause for retinal degenerative diseases.
Yoshiyuki Henning, Karol Szafranski
doaj   +1 more source