Results 101 to 110 of about 9,324 (271)

Shining light on an mGlu5 photoswitchable NAM: A theoretical perspective [PDF]

open access: yes, 2016
Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a particularly high-profile target because its positive or negative allosteric modulation can ...
A.R. Dalton, James   +11 more
core   +5 more sources

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

open access: yesAdvanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao   +6 more
wiley   +1 more source

Ultrafast Electronic Energy Transfer in an orthogonal molecular dyad [PDF]

open access: yes, 2017
The St Andrews group acknowledges support from the European Research Council (grant number 321305) and the Engineering and Physical Sciences Research Council (grant EP/L017008/1). I.D.W.S.
Arvydas Ruseckas   +8 more
core   +5 more sources

Traceless Regulation of Genetic Circuitry

open access: yesAdvanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Ring closing reaction in diarylethene captured by femtosecond electron crystallography [PDF]

open access: yes, 2013
The photoinduced ring-closing reaction in diarylethene, which serves as a model system for understanding reactive crossings through conical intersections, was directly observed with atomic resolution using femtosecond electron diffraction.
Asano Y.   +58 more
core   +1 more source

Bistable Dual‐Responsive Azobenzene‐co‐PNIPAM Soft Microactuators via Two‐Photon Direct Laser Writing

open access: yesAdvanced Intelligent Systems, EarlyView.
This work shows the successful integration of intrinsic bistability into thermoresponsive soft microactuators, fabricated by two‐photon polymerization utilizing the (E)–(Z)‐isomerization of azobenzenes. The bistable behavior accounts for a reversible volume change of Azo_pNIPAM microactuators initiated by light irradiation, at constant ambient ...
Chantal Barwig   +13 more
wiley   +1 more source

From:E to Z and back again: Reversible photoisomerisation of an isolated charge-tagged azobenzene [PDF]

open access: yes, 2018
Substituted azobenzenes serve as chromophores and actuators in a wide range of molecular photoswitches. Here, tandem ion mobility spectrometry coupled with laser excitation is used to investigate the photoisomerisation of selected E and Z isomers of the ...
Adamson   +40 more
core   +2 more sources

Reversible Fluorescence Photoswitching in DNA [PDF]

open access: yesThe Journal of Physical Chemistry B, 2012
We describe the engineering of reversible fluorescence photoswitching in DNA with high-density substitution, and its applications in advanced fluorescence microscopy methods. High-density labeling of DNA with cyanine dyes can be achieved by polymerase chain reaction using a modified DNA polymerase that has been evolved to efficiently incorporate Cy3 ...
Smith, Darren A.   +2 more
openaire   +3 more sources

NASA propulsion controls research [PDF]

open access: yes
Multivariable control theory is applied to the design of multiple input and output engine controls. Highly-accurate, real-time engine simulations are utilized for control development and checkout.
Teren, F.
core   +1 more source

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