Results 41 to 50 of about 9,324 (271)
Conductance of a single molecule anchored by an isocyanide substituent to gold electrodes [PDF]
, 2006 The effect of anchoring group on the electrical conductance of a single molecule bridging two Au electrodes was studied using di-substituted (isocyanide (CN-), thiol (S-) or cyanide (NC-)) benzene.
Cunningham I. D. +5 more
core +2 more sources
Optocontrol of glutamate receptor activity by single side-chain photoisomerization
eLife, 2017 Engineering light-sensitivity into proteins has wide ranging applications in molecular studies and neuroscience. Commonly used tethered photoswitchable ligands, however, require solvent-accessible protein labeling, face structural constrains, and are ...
Viktoria Klippenstein +4 more
doaj +1 more source
Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics
Applied Sciences, 2020 Synthetic optogenetics is an emerging optical technique that enables users to photocontrol molecules, proteins, and cells in vitro and in vivo. This is achieved by use of synthetic chromophores—denoted photoswitches—that undergo light ...
Shai Kellner, Shai Berlin
doaj +1 more source
2D-IR Study of a Photoswitchable Isotope-Labeled α-Helix [PDF]
, 2010 A series of photoswitchable, α-helical peptides were studied using two-dimensional infrared spectroscopy (2D-IR). Single-isotope labeling with 13C18O at various positions in the sequence was employed to spectrally isolate particular backbone positions ...
Backus, E H G +7 more
core +1 more source
Bistable Photoswitch Allows in Vivo Control of Hematopoiesis
ACS Central Science, 2021 Optical control has enabled functional modulation in cell culture with unparalleled spatiotemporal resolution. However, current tools for in vivo manipulation are scarce.
Lea Albert +17 more
semanticscholar +1 more source
Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. [PDF]
, 2012 Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofol (2,6-diisopropylphenol), a ...
Bruzik, Karol S +8 more
core +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Mechanisms of anesthesia remain obscure. We developed a β-subunit-specific tethered photoswitch containing the widely used anesthetic, propofol, to study the anesthetic mechanisms through γ-aminobutyric acid type A (GABAA) receptors critical
C. Borghese +6 more
semanticscholar +1 more source
Vinylene-Linked Covalent Organic Frameworks by Base-Catalyzed Aldol Condensation [PDF]
, 2019 Two 2D covalent organic frameworks (COFs) linked by vinylene (−CH=CH−) groups (V‐COF‐1 and V‐COF‐2) are synthesized by exploiting the electron deficient nature of the aromatic s‐triazine unit of C3‐symmetric 2,4,6‐trimethyl‐s‐triazine (TMT).
Acharjya, Amitava +4 more
core +1 more source
Supramolecular hierarchy among halogen and hydrogen bond donors in light-induced surface patterning [PDF]
, 2015 Halogen bonding, a noncovalent interaction possessing several unique features compared to the more familiar hydrogen bonding, is emerging as a powerful tool in functional materials design.
Barrett C. J. +10 more
core +1 more source
bioRxivRed light optogenetic systems are in high demand for the precise control of gene expression for gene- and cell-based therapies. Here, we report a red/far-red light-inducible photoswitch (REDLIP) system based on the chimeric photosensory protein FnBphP ...
Longliang Qiao +6 more
semanticscholar +1 more source