Results 61 to 70 of about 2,726 (151)

GLT1 overexpression in SOD1G93A mouse cervical spinal cord does not preserve diaphragm function or extend disease

Neurobiology of Disease, 2015
Amyotrophic lateral sclerosis (ALS) is characterized by relatively rapid degeneration of both upper and lower motor neurons, with death normally occurring 2–5 years following diagnosis primarily due to respiratory paralysis resulting from phrenic motor ...
Ke Li, Tamara J. Hala, Suneil Seetharam, David J. Poulsen, Megan C. Wright, Angelo C. Lepore   +5 more
doaj   +1 more source

Maturation of spinal motor control through developmental changes in ion currents

The Journal of Physiology, EarlyView.
Abstract figure legend Ion channels of spinal neurons have been shown to change during development in a wide range of species. These changes occur at specific stages of development. An important developmental process is the maturation of motor control by which the body acquires new movements or refines movements already present.
Stephanie F. Gaudreau, Tuan V. Bui
wiley   +1 more source

Brachial Plexus Wrapping by Free Perforator Fat Flap for Treatment of Recurrent Neurogenic Thoracic Outlet Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT A 35‐year‐old woman with recurrent neurogenic thoracic outlet syndrome underwent supraclavicular neurolysis and brachial plexus wrapping using a free DIEP flap. At 2‐year follow‐up, pain and functional scores (VAS, DASH, SF‐36) significantly improved. Free fat flaps offer a low morbidity option for reducing perineural fibrosis in RNTOS.
F. Thuau, G. Gadbled, B. Pradier, P. Perrot, U. Lancien   +4 more
wiley   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, Volume 4, Issue 2, June 2026.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes

Disease Models & Mechanisms, 2017
The pathogenic drivers of sporadic and familial motor neuron disease (MND), such amyotrophic lateral sclerosis (ALS), are unknown. MND impairs the Ran GTPase cycle, which controls nucleocytoplasmic transport, ribostasis and proteostasis; however, cause ...
Kyoung-in Cho, Dosuk Yoon, Sunny Qiu, Zachary Danziger, Warren M. Grill, William C. Wetsel, Paulo A. Ferreira   +6 more
doaj   +1 more source

Tramadol‐Induced Persistent Singultus: A Case Report on Diagnosis, Mechanism, and Management

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hiccups, or singultus, are involuntary diaphragmatic contractions followed by the sudden closure of the glottis, resulting in a characteristic sound. These episodes are generally transient but can be classified as acute (lasting < 48 h), persistent (lasting > 48 h), or intractable (lasting > 1 month).
Ambika Nand Jha, Varsha Ratan Gaikwad, Abdullah Al Noman, Pranab Dev Sharma   +3 more
wiley   +1 more source

SMΝΔ7 mice show breathing and airflow defects with significant pathology of respiratory and oral tract tissues

Frontiers in Cellular Neuroscience
IntroductionSpinal muscular atrophy (SMA) is a neurodegenerative disorder caused by SMN1 mutations, leading to SMN protein deficiency and motor neuron loss.
Roxanne Muchow, Roxanne Muchow, Michelle Woolridge, Michelle Woolridge, Catherine L. Smith, Catherine L. Smith, F. Javier Llorente Torres, F. Javier Llorente Torres, Dennis Perez-Lopez, Dennis Perez-Lopez, Nicole L. Nichols, Nicole L. Nichols, Monique A. Lorson, Monique A. Lorson, Christian L. Lorson, Christian L. Lorson   +15 more
doaj   +1 more source

Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase.

PLoS ONE, 2014
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease leading to motor neuron dysfunction resulting in impairment of neuromuscular transmission. A2A adenosine receptors have already been considered as a potential therapeutical target for ALS
Filipe Nascimento, Paula A Pousinha, Alexandra M Correia, Rui Gomes, Ana M Sebastião, Joaquim A Ribeiro   +5 more
doaj   +1 more source

Teashirt1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons [PDF]

Development, 2019
Breathing and feeding are essential motor functions and rely on the activity of hypoglossal and phrenic motor neurons that innervate the tongue and diaphragm, respectively. Little is known about the genetic programs that control the development of these neuronal subtypes.
Charlotte Chaimowicz, Pierre-Louis Ruffault, Cyril Chéret, Andrew Woehler, Niccolò Zampieri, Gilles Fortin, Alistair N. Garratt, Carmen Birchmeier   +7 more
openaire   +2 more sources