Results 41 to 50 of about 2,726 (151)

A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function

Neurobiology of Disease, 2019
We tested a biomaterial-based approach to preserve the critical phrenic motor circuitry that controls diaphragm function by locally delivering minocycline hydrochloride (MH) following cervical spinal cord injury (SCI).
Biswarup Ghosh, Jia Nong, Zhicheng Wang, Mark W. Urban, Nicolette M. Heinsinger, Victoria A. Trovillion, Megan C. Wright, Angelo C. Lepore, Yinghui Zhong   +8 more
doaj   +1 more source

Phrenic Motor Neuron Survival Caudal to C2 Hemisection

The FASEB Journal, 2017
Cervical spinal injury (cSCI) severs descending brainstem projections to spinal respiratory motor neurons, paralyzing respiratory muscles caudal to injury. Spinal hemisection at C2 (C2Hx) has frequently been used as an experimental model of cSCI to study both spontaneous and induced functional recovery of both respiratory and non‐respiratory somatic ...
Latoya Lynn Allen, Juliet V Santiago, Zachary A Asa, Ashley E Holland, Marissa Ciesla, Irawan S Satriotomo, Gordon S Mitchell, Elisa Janine Gonzalez‐Rothi   +7 more
openaire   +1 more source

A closed-loop model of the respiratory system: focus on hypercapnia and active expiration. [PDF]

PLoS ONE, 2014
Breathing is a vital process providing the exchange of gases between the lungs and atmosphere. During quiet breathing, pumping air from the lungs is mostly performed by contraction of the diaphragm during inspiration, and muscle contraction during ...
Yaroslav I Molkov, Natalia A Shevtsova, Choongseok Park, Alona Ben-Tal, Jeffrey C Smith, Jonathan E Rubin, Ilya A Rybak   +6 more
doaj   +1 more source

Combination of a Gellan Gum-Based Hydrogel With Cell Therapy for the Treatment of Cervical Spinal Cord Injury

Frontiers in Bioengineering and Biotechnology, 2020
Cervical spinal cord trauma represents more than half of the spinal cord injury (SCI) cases worldwide. Respiratory compromise, as well as severe limb motor deficits, are among the main consequences of cervical lesions.
Eduardo D. Gomes, Eduardo D. Gomes, Biswarup Ghosh, Rui Lima, Rui Lima, Miguel Goulão, Miguel Goulão, Miguel Goulão, Tiago Moreira-Gomes, Tiago Moreira-Gomes, Joana Martins-Macedo, Joana Martins-Macedo, Mark W. Urban, Megan C. Wright, Jeffrey M. Gimble, Nuno Sousa, Nuno Sousa, Nuno A. Silva, Nuno A. Silva, Angelo C. Lepore, António J. Salgado, António J. Salgado   +21 more
doaj   +1 more source

Segmental composition and nerve distribution of the brachial plexus in Galictis cuja

The Anatomical Record, EarlyView.
Abstract Galictis cuja is a neotropical mustelid with terrestrial locomotor habits, yet the anatomy of its brachial plexus has remained undescribed. This study characterizes the origin, organization, and distribution of the brachial plexus nerves in 15 adult specimens (30 antimeres).
Natan da Cruz de Carvalho, Thais Mattos Estruc, Ingrid Bete Palmeira, Julia Fagundes Franco, Emillin Reis Bermudez, Paulo de Souza‐Junior, Marcelo Abidu‐Figueiredo   +6 more
wiley   +1 more source

Thickening fraction as a measure of ultrasonographic diaphragm dysfunction in amyotrophic lateral sclerosis

Clinical Neurophysiology Practice, 2020
Objective: Respiratory failure is the most common cause of death in ALS patients secondary to diaphragmatic dysfunction. Herein, we report three ALS patients, and we sought to determine the diaphragm dysfunction by the measurement of ultrasonographic ...
Lakshmi P. Digala, Raghav Govindarajan
doaj   +1 more source

Donor‐To‐Recipient Mean Axonal Count Ratios of Upper Limb Nerves Used in Nerve Transfer Surgery: A Systematic Review of Histomorphometric Cadaveric Studies

Clinical Anatomy, EarlyView.
ABSTRACT Nerve transfer surgery may be performed to restore sensorimotor function following peripheral nerve trauma or dysfunction. There is biological plausibility and limited correlative evidence that donor‐to‐recipient axon count ratios may impact functional outcomes.
Samuel James Ng, Rosa Morgan‐Young, Alexander Laing, Rebecca Molden, Suzanne Thomson   +4 more
wiley   +1 more source

Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats

Epilepsia, EarlyView.
Abstract Objective Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic–clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic ...
Auriane Apaire, Elise Collard, Abigail Niyibizi, Natasha N. Kumar, Enrique Germany Morrison, Javier Chavez Cerda, Ayse S. Dereli, Riem El Tahry   +7 more
wiley   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats

Function
Acute intermittent hypoxia (AIH) elicits respiratory motor plasticity in the phrenic, intercostal, and hypoglossal motor pools and has emerged as a promising therapeutic strategy to improve respiratory function in people with neuromuscular disorders that
Aaron A. Jones, Alexandria B. Marciante, Pierce Berardi, Gordon S. Mitchell   +3 more
doaj   +1 more source