Results 21 to 30 of about 2,726 (151)

Trophic factor expression in phrenic motor neurons [PDF]

Respiratory Physiology & Neurobiology, 2008
The function of a motor neuron and the muscle fibers it innervates (i.e., a motor unit) determines neuromotor output. Unlike other skeletal muscles, respiratory muscles (e.g., the diaphragm, DIAm) must function from birth onwards in sustaining ventilation.
Carlos B, Mantilla, Gary C, Sieck
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Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7

Disease Models & Mechanisms, 2021
Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion in the coding region of the ataxin-7 gene.
Anna F. Fusco, Logan A. Pucci, Pawel M. Switonski, Debolina D. Biswas, Angela L. McCall, Amanda F. Kahn, Justin S. Dhindsa, Laura M. Strickland, Albert R. La Spada, Mai K. ElMallah   +9 more
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Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Journal of Neuroinflammation, 2021
Background Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been extensively studied, its effects on plasticity of neural networks controlling vital life ...
Arash Tadjalli, Yasin B. Seven, Raphael R. Perim, Gordon S. Mitchell   +3 more
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Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice [PDF]

Journal of Visualized Experiments, 2018
Phrenic motor neurons are cervical motor neurons originating from C3 to C6 levels in most mammalian species. Axonal projections converge into phrenic nerves innervating the respiratory diaphragm. In spinal cord slices, phrenic motor neurons cannot be identified from other motor neurons on morphological or biochemical criteria.
Vandeweerd, Jean-Michel, Hontoir, Fanny, De Knoop, Alexis, De Swert, Kathleen, Nicaise, Charles   +4 more
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Phrenic-specific transcriptional programs shape respiratory motor output

eLife, 2020
The precise pattern of motor neuron (MN) activation is essential for the execution of motor actions; however, the molecular mechanisms that give rise to specific patterns of MN activity are largely unknown.
Alicia N Vagnozzi, Kiran Garg, Carola Dewitz, Matthew T Moore, Jared M Cregg, Lucie Jeannotte, Niccolò Zampieri, Lynn T Landmesser, Polyxeni Philippidou   +8 more
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Phrenic Long-Term Facilitation Requires PKCθ Activity within Phrenic Motor Neurons [PDF]

The Journal of Neuroscience, 2015
Acute intermittent hypoxia (AIH) induces a form of spinal motor plasticity known as phrenic long-term facilitation (pLTF); pLTF is a prolonged increase in phrenic motor output after AIH has ended. In anesthetized rats, we demonstrate that pLTF requires activity of the novel PKC isoform, PKCθ, and that the relevant PKCθ is within phrenic motor neurons ...
Michael J. Devinney, Daryl P. Fields, Adrianne G. Huxtable, Timothy J. Peterson, Erica A. Dale, Gordon S. Mitchell   +5 more
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Decreased spinal synaptic inputs to phrenic motor neurons elicit localized inactivity-induced phrenic motor facilitation [PDF]

Experimental Neurology, 2014
Phrenic motor neurons receive rhythmic synaptic inputs throughout life. Since even brief disruption in phrenic neural activity is detrimental to life, on-going neural activity may play a key role in shaping phrenic motor output. To test the hypothesis that spinal mechanisms sense and respond to reduced phrenic activity, anesthetized, ventilated rats ...
K A, Streeter, T L, Baker-Herman
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Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS

Neurobiology of Disease, 2006
The transgenic mutant superoxide dismutase (SOD1) mice and rats have been important tools in attempting to understand motor neuron pathology and degeneration but the mechanism behind death in this model has not been studied.
Jerònia Lladó, Christine Haenggeli, Andrea Pardo, Victor Wong, Leah Benson, Carol Coccia, Jeffrey D. Rothstein, Jeremy M. Shefner, Nicholas J. Maragakis   +8 more
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Glutamatergic Neurotransmission at Rat Phrenic Motor Neurons

The FASEB Journal, 2020
Glutamatergic (Glu) synaptic inputs at phrenic motor neurons (PhMNs) predominantly comprise descending axons from respiratory centers in the ventrolateral medulla. Descending synaptic inputs provide the drive for inspiratory as well as various other behaviors that result in higher force ...
Carlos B. Mantilla, Sabhya Rana, Wen-Zhi Zhan, Gary C. Sieck   +3 more
openaire   +1 more source

Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats

Neurobiology of Disease, 2010
In amyotrophic lateral sclerosis (ALS), the exogenous temporal triggers that result in initial motor neuron death are not understood. Overactivation and consequent accelerated loss of vulnerable motor neurons is one theory of disease initiation.
Angelo C. Lepore, Christopher Tolmie, John O'Donnell, Megan C. Wright, Christine Dejea, Britta Rauck, Ahmet Hoke, Anthony R. Ignagni, Raymond P. Onders, Nicholas J. Maragakis   +9 more
doaj   +1 more source