Spinal TNF-α receptor 1 is differentially required for phrenic long-term facilitation (pLTF) over the course of motor neuron death in adult rats [PDF]
Frontiers in PhysiologyIntroductionIntrapleural injections of cholera toxin B conjugated to saporin (CTB-SAP) result in selective respiratory (e.g., phrenic) motor neuron death and mimics aspects of motor neuron disease [(e.g., amyotrophic lateral sclerosis (ALS) and spinal ...
Ryan D. Lewis +7 more
doaj +2 more sources
Microglia regulate motor neuron plasticity via reciprocal fractalkine and adenosine signaling [PDF]
Nature CommunicationsWe report an important role for microglia in regulating neuroplasticity within phrenic motor neurons. Brief episodes of low oxygen (acute intermittent hypoxia; AIH) elicit a form of respiratory motor plasticity known as phrenic long-term facilitation ...
Alexandria B. Marciante +9 more
doaj +2 more sources
Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons [PDF]
Development (Cambridge), 2014 Air breathing is an essential motor function for vertebrates living on land. The rhythm that drives breathing is generated within the central nervous system and relayed via specialised subsets of spinal motor neurons to muscles that regulate lung volume.
Carolina Barcellos Machado +2 more
exaly +6 more sources
Cervical spinal hemisection alters phrenic motor neuron glutamatergic mRNA receptor expression [PDF]
Experimental Neurology, 2022 Sabhya Rana +2 more
exaly +2 more sources
A cholinergic spinal pathway for the adaptive control of breathing [PDF]
Cell ReportsSummary: The ability to amplify motor neuron (MN) output is essential for generating high-intensity motor actions. This is critical for breathing that must be rapidly adjusted to accommodate changing metabolic demands.
Minshan Lin +9 more
doaj +2 more sources
Communications BiologyThe fatal motor neuron (MN) disease Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive MN degeneration. Phrenic MNs (phMNs) controlling the activity of the diaphragm are prone to degeneration in ALS, leading to death by respiratory ...
Louise Thiry +3 more
doaj +4 more sources
Enhanced phrenic motor neuron BDNF expression elicited by daily acute intermittent hypoxia is undermined in rats with chronic cervical spinal cord injury [PDF]
Respiratory Physiology and NeurobiologyAaron A Jones +2 more
exaly +2 more sources
The evidence for old age motor neuron death: A scoping review. [PDF]
Physiol RepWe systematically evaluated the extant literature on age‐related motor neuron (MN) death in aging, focusing on studies directly assessing MNs. We show that in the spinal cord and brainstem, there is robust evidence for MN loss, particularly in the human spinal cord. In rats, MN loss was readily observed across a variety of labelling methods and regions,
Cheung SW, Fogarty MJ.
europepmc +2 more sources
Corrigendum: Spinal TNF-α receptor 1 is differentially required for phrenic long-term facilitation (pLTF) over the course of motor neuron death in adult rats [PDF]
Frontiers in PhysiologyRyan D. Lewis +7 more
doaj +2 more sources
Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development. [PDF]
PLoS ONE, 2013 Central nervous system GABAergic and glycinergic synaptic activity switches from postsynaptic excitation to inhibition during the stage when motor neuron numbers are being reduced, and when synaptic connections are being established onto and by motor ...
Matthew J Fogarty +5 more
doaj +1 more source